Fossilized eggs crack open the mysteries of the past | CNN

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CNN
 — 

Eggs have been laid on land by birds, reptiles, dinosaurs and a few oddball mammals for more than 200 million years.

And humans have been using some of these eggs as a nutritious source of food, and their shells as bowls, bottles and jewelry for most of our history on the planet.

Though they’ve often been overshadowed by skeletons and bones, fossilized eggshells are a fascinating source of information, illuminating the behavior and diet of ancient creatures, detailing changes in climate and revealing how our prehistoric relatives lived and communicated.

This Easter, here are six surprising things eggs have revealed about the past.

Did dinosaur blood run cold, like a lizard, or warm, like a bird? It’s a topic that’s long divided paleontologists.

An analysis of fossilized dinosaur egg shells suggests it’s the latter. By looking at the order of oxygen and carbon atoms in the fossilized egg shells, researchers were able to calculate a dinosaur mom’s internal body temperature. It’s a process called “clumped isotope paleothermometry.”

“Eggs, because they are formed inside dinosaurs, act like ancient thermometers,” said Pincelli Hull, an assistant professor at Yale University’s department of geology and geophysics, and a coauthor of the study, which published in 2020.

Hull and her colleagues found that the samples they tested suggested dinosaurs’ body temperatures were warmer than their surroundings would have been.

The research indicates that unlike reptiles, which rely on heat from the environment, dinosaurs were capable of internally generating heat – more like birds.

A study of fossilized eggshells revealed humans may have been hatching and raising cassowaries for more than 18,000 years.

You might think that chickens—or even ducks or turkeys—were the earliest birds to be domesticated by humans.

However, eggshell fragments found at two prehistoric sites in Papua New Guinea suggest that humans may have been raising cassowaries—often described as the world’s most dangerous birds because of a daggerlike claw they have on each foot—as early as 18,000 years ago.

Territorial, aggressive and often compared to a dinosaur in looks, the bird is a surprising candidate for domestication. But a study of more than 1,000 fossilized Papua New Guinea eggshell fragments has suggested the birds were deliberately hatched.

To reach their conclusions, the researchers first studied the eggshells of living birds, including turkeys, emus and ostriches. The insides of the eggshells change as the developing chicks get calcium from the eggshell. Using high-resolution 3D images and inspecting the inside of the eggs, the researchers were able to build a model of what the eggs looked like during different stages of incubation.

The scientists tested their model on modern emu and ostrich eggs before applying it to the fossilized eggshell fragments found in New Guinea. The team found that most of the eggshells found at the sites were all near maturity—suggesting they were hatched, not eaten.

The first oviraptor fossil—from a family of dinosaurs with parrotlike beaks—was discovered in Mongolia in the 1920s, lying near a nest of eggs thought to belong to a rival. Paleontologists at the time assumed that the animal had died while attempting to plunder the nest and named the creature “egg thief.”

It wasn’t until the 1990s that its reputation was restored when another discovery revealed that the eggs were its own. Subsequent finds, including an oviraptosaur hunched over 24 eggs made public last year, have revealed that this particular type of dinosaur was a doting parent.

At least seven of the 24 eggs preserved the bones of partial embryos found inside; it was the first time a fossil had preserved this level of detail. These embryos were at a late stage of development, and the close proximity of the parent confirmed that this dinosaur really did incubate its nest like its modern bird cousins.

The neat layout of oviraptor nests also suggested that they were brooders that sat upon eggs to hatch them—even giant oviraptors that weighed 1,500 kilograms (3,307 pounds) and laid half-meter long eggs, said Darla Zelenitsky, a dinosaur egg expert and associate professor in the department of geoscience at the University of Calgary in Canada.

“These fossils also show very precisely arranged eggs, stacked in rings, probably optimized for sitting on the eggs,” she explained.

The 2-meter-wide (6.6-foot-wide) nests of giant oviraptors were a slightly modified shape to stop them from being crushed, she added.

Dinosaurs eggs—including one with a perfectly preserved baby dinosaur curled up inside—increasingly show that birds inherited many characteristics from dinosaurs. Not all dinosaurs, however, were caring parents.

Pores on the surface of eggs allow the diffusion of water, oxygen and carbon dioxide, and the orientation, density and number of pores on the eggs of living animals can reveal whether they are laid in open nests or underground. Applying this knowledge to fossilized dinosaur eggs has shed light on their nesting behavior.

Analysis suggests that many dinosaurs, including hulking plant-eating sauropods, laid their eggs underground in burrows, more like reptiles.

A string of modern ostrich eggshell beads from eastern Africa is shown.

Ostrich eggshells are found in archaeological dig sites throughout Africa. Early humans used the large eggs as water bottles and, for tens of thousands of years, ancient humans took the remains and fashioned them into decorative beads that are still made today.

These beads have been found all over Africa—including in areas where ostriches never lived – sparking the question of how they got there.

The answer is hidden in the eggs’ geochemistry. Researchers looked at the signatures of different isotopes or variants of the element strontium in the beads—these vary depending on where the ostriches would have fed before laying the eggs.

Older rock formations including granite are found to have more strontium than younger rocks like basalt, and this is reflected in the vegetation that grows around them.

The geochemistry of the beads showed they traveled long distances. They were traded or exchanged in what was described as an early social network.

Eggs are a big part of our diet today – something that was also true in the Stone Age.

In fact, ancient Australians’ appetite for the eggs laid by the 2-meter-tall (6-foot-tall) Genyornis could have been one significant reason why the large, flightless birds went extinct 47,000 years ago.

Burn patterns on eggshell fragments of the giant bird found at around 200 sites across Australia, were created by humans discarding eggshell in and around makeshift fires, presumably made to cook the eggs.

Chemical signatures of nitrogen and carbon isotopes in fossilized egg shells can also track vegetation changes, gleaning information about past changes in climate, which can reveal ecological shifts that could impact the survival of these species over time.

A study of emu eggshells found across Australia over a 100,000-year time period do not show a massive shift in climate that researchers believe could have led to the extinction of Genyornis.

This suggested that the extinction of these giant birds was caused by humans, not ecological changes, the study said.

Fossilized penguin, ostrich and emu eggshells have revealed what the climate was like in the ancient Antarctic, South Africa and Australia. More recent egg collections are revealing how the current climate crisis is changing the natural world today.

By comparing birds’ eggs collected during the Victorian era and modern eggs held by the Field Museum and other institutions, researchers found that several bird species in the Chicago area nest and lay eggs almost a full month earlier now than they did a century ago.

Of the 72 species documented in the data, a third have been nesting earlier and earlier, the team found. Birds that changed their nesting habits laid eggs around 25 days sooner, on average.

Similar patterns are seen in insects, which many birds eat, and plants, suggesting that climate change is already changing ecosystems, the authors of the study said.

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Newly discovered ‘einstein’ shape can do something no other tile can do | CNN

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CNN
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A geometry problem that has been puzzling scientists for 60 years has likely just been solved by an amateur mathematician with a newly discovered 13-sided shape.

Called “The hat” because it vaguely resembles a fedora, the elusive shape is an “einstein” (from the German “ein stein,” or “one stone”). That means it can completely cover a surface without ever creating a repeated pattern — something that had not yet been achieved with a single tile.

“I’m always looking for an interesting shape, and this one was more than that,” said David Smith, its creator and a retired printing technician from northern England, in a phone interview. Soon after discovering the shape in November 2022, he contacted a math professor and later, with two other academics, they released a self-published scientific paper about it.

“I’m not really into math, to be honest — I did it at school, but I didn’t excel in it,” Smith said. That’s why I got these other guys involved, because there’s no way I could have done this without them. I discovered the shape, which was a bit of luck, but it was also me being persistent.”

Most wallpapers or tiles in the real world are periodic, meaning you can identify a small cluster that’s just constantly repeated to cover the whole surface. “The hat,” however, is an aperiodic tile, meaning it can still completely cover a surface without any gaps, but you can never identify any cluster that periodically repeats itself to do so.

Fascinated by the idea that such aperiodic sets of shapes could exist, mathematicians first mulled the problem in the early 1960s, but they initially believed the shapes were impossible. That turned out to be wrong, because within years a set of 20,426 tiles that — when used together — could do the job was created. That number was soon reduced to just over 100, and then down to six.

In the 1970s, the work of British physicist and Nobel Prize winner Roger Penrose further reduced the number of shapes from six down to two in a system that has since been known as Penrose tiling. And that’s where things were stuck for decades.

Smith became interested in the problem in 2016, when he launched a blog on the subject. Six years later, in late 2022, he thought he had bested Penrose in finding the einstein, so he got in touch with Craig Kaplan, a professor in the School of Computer Science at the University of Waterloo in Canada.

“From my perspective, it started with an email out of blue,” Kaplan said in a phone interview. “David knew that I had recently published a paper describing a piece of software that could help him understand what was going on with the tile.”

With the help of the software, the two realized they were onto something.

There’s nothing inherently magical about “The hat,” according to Kaplan.

“It’s really a very simple polygon to describe. It doesn’t have weird, irrational angles, it’s basically just something you get by cutting up hexagons.” For that reason, he adds, it might have been “discovered” in the past by other mathematicians creating similar shapes, but they just did not think about checking its tiling properties.

The finding has created quite a stir since its release in late March. As Kaplan points out, it has inspired artistic renditions, knitted quilts, cookie cutters, TikTok explainers and even a joke in one of Jimmy Kimmel’s opening monologues.

“I think it might open a few doors,” Smith said, “I’ve got a feeling we’ll have a different way of looking at how to find these sorts of anomalies, if you like.”

The shape is publicly available, even for 3D printing, and it’s not going to be copyrighted.

“We’re not trying to protect it in any way,” Kaplan said. “It belongs to everyone, and I hope people will use this in all kinds of decorative, architectural and artistic content.”

What about bathroom tiling? “I can only hope we’ll see lots of bathrooms decorated with it, but it’s going to be a little bit tricky,” he added. “One of the reasons we use periodic tilings in places like bathrooms is because the rule for how to lay them is pretty simple. With this, you have a different challenge — you could potentially start laying it down out and hack yourself into a corner where you’ve created a space that you can’t fill with more hats.”

Far from being content with having rewritten math history, Smith has already discovered a “sequel” to “The hat.” Called “The turtle,” the new shape is also an einstein, but it’s made of 10 kites, or sections, rather than eight, and therefore bigger than “The hat.”

“It’s a bit of an addiction,” Smith confessed about his constant quest for new shapes.

The scientific paper on “The hat,” coauthored with Joseph Myers, a software developer, and Chaim Goodman-Strauss, a mathematician at the University of Arkansas, has not yet gone through peer review — the process of verification by other scientists that is standard in scientific publications — but will do so over the next few months.

“I really look forward to seeing what comes out of that process,” Kaplan said, acknowledging that it could mean that the findings could be disputed. “I believe strongly in the importance of peer review as a way of conducting science. So, until that happens, I would agree that there should be reason to not be certain yet. But based on the evidence that we accumulated, it’s hard to imagine a way that we could be wrong.”

The discovery, once confirmed, could be significant across other fields of research, according to Rafe Mazzeo, a professor in the department of mathematics at Stanford University, who was not involved in the study.

“Tilings have many applications in physics, chemistry and beyond, for example in the study of crystals,” he said in an email. “The discovery of aperiodic tilings, now many years ago, created a stir, since their existence was so unexpected.

“This new discovery is a strikingly simple example. There are no standard techniques known for finding new aperiodic tiles, so this involved a really new idea. That is always exciting,” he added.

Mazzeo said it’s also nice to hear of a mathematical discovery that is so easy to visualize and explain: “This illustrates that mathematics is still a growing subject, with many problems that have not yet been solved.”



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A new approach to a Covid-19 nasal vaccine shows early promise | CNN



CNN
 — 

Scientists in Germany say they’ve been able to make a nasal vaccine that can shut down a Covid-19 infection in the nose and throat, where the virus gets its first foothold in the body.

In experiments in hamsters, two doses of the vaccine – which is made with a live but weakened form of the coronavirus that causes Covid-19 – blocked the virus from copying itself in the animals’ upper airways, achieving “sterilizing immunity” and preventing illness, a long-sought goal of the pandemic.

Although this vaccine has several more hurdles to clear before it gets to a doctor’s office or drug store, other nasal vaccines are in use or are nearing the finish line in clinical trials.

China and India both rolled out vaccines given through the nasal tissues last fall, though it’s not clear how well they may be working. Studies on the effectiveness of these vaccines have yet to be published, leaving much of the world to wonder whether this approach to protection really works in people.

The US has reached something of a stalemate with Covid-19. Even with the darkest days of the pandemic behind us, hundreds of Americans are still dying daily as the infection continues to simmer in the background of our return to normal life.

As long as the virus continues to spread among people and animals, there’s always the potential for it mutate into a more contagious or more damaging version of itself. And while Covid infections have become manageable for most healthy people, they may still pose a danger to vulnerable groups such as the elderly and immunocompromised.

Researchers hope next-generation Covid-19 vaccines, which aim to shut down the virus before it ever gets a chance to make us sick and ultimately prevent the spread of infection, could make our newest resident respiratory infection less of a threat.

One way scientists are trying to do that is by boosting mucosal immunity, beefing up immune defenses in the tissues that line the upper airways, right where the virus would land and begin to infect our cells.

It’s a bit like stationing firefighters underneath the smoke alarm in your house, says study author Emanuel Wyler, a scientist at the Max Delbruck Center for Molecular Medicine in the Helmholtz Association in Berlin.

The immunity that’s created by shots works throughout the body, but it resides primarily in the blood. That means it may take longer to mount a response.

“If they are already on site, they can immediately eliminate the fire, but if they’re like 2 miles away, they first need to drive there, and by that time, one-third of the house is already in full flames,” Wyler said.

Mucosal vaccines are also better at priming a different kind of first responder than injections do. They do a better job of summoning IgA antibodies, which have four arms to grab onto invaders instead of the two arms that the y-shaped IgG antibodies have. Some scientists think IgA antibodies may be less picky about their targets than IgG antibodies, which makes them better equipped to deal with new variants.

The new nasal vaccine takes a new approach to a very old idea: weakening a virus so it’s no longer a threat and then giving it to people so their immune systems can learn to recognize and fight it off. The first vaccines using this approach date to the 1870s, against anthrax and rabies. Back then, scientists weakened the agents they were using with heat and chemicals.

The researchers manipulated the genetic material in the virus to make it harder for cells to translate. This technique, called codon pair deoptimization, hobbles the virus so it can be shown to the immune system without making the body sick.

“You could imagine reading a text … and every letter is a different font, or every letter is a different size, then the text is much harder to read. And this is basically what we do in codon pair deoptimization,” Wyler said.

In the hamster studies, which were published Monday in the journal Nature Microbiology, two doses of the live but weakened nasal vaccine created a much stronger immune response than either two doses of an mRNA-based vaccine or one that uses an adenovirus to ferry the vaccine instructions into cells.

The researchers think the live weakened vaccine probably worked better because it closely mimics the process of a natural infection.

The nasal vaccine also previews the entire coronavirus for the body, not just its spike proteins like current Covid-19 vaccines do, so the hamsters were able to make immune weapons against a wider range of targets.

As promising as all this sounds, vaccine experts say caution is warranted. This vaccine still has to pass more tests before it’s ready for use, but they say the results look encouraging.

“They did a very nice job. This is obviously a competent and thoughtful team that did this work, and impressive in the scope of what they did. Now it just needs to be repeated,” perhaps in primates and certainly in humans before it can be widely used, said Dr. Greg Poland, who designs vaccines at the Mayo Clinic. He was not involved in the new research.

The study began in 2021, before the Omicron variant was around, so the vaccine tested in these experiments was made with the original strain of the coronavirus. In the experiments, when they infected animals with Omicron, the live but weakened nasal vaccine still performed better than the others, but its ability to neutralize the virus was diminished. Researchers think it will need an update.

It also needs to be tested in humans, and Wyler says they’re working on that. The scientists have partnered with a Swiss company called RocketVax to start phase I clinical trials.

Other vaccines are further along, but the progress has been “slow and halting,” Poland said. Groups working on these vaccines are struggling to raise the steep costs of getting a new vaccine to market, and they’re doing it in a setting where people tend to think the vaccine race has been won and done.

In reality, Poland said, we’re far from that. All it would take is another Omicron-level shift in the evolution of the virus, and we could be back at square one, with no effective tools against the coronavirus.

“That’s foolish. We should be developing a pan-coronavirus vaccine that does induce mucosal immunity and that is long-lived,” he said.

At least four nasal vaccines for Covid-19 have reached late-stage testing in people, according to the World Health Organization’s vaccine tracker.

The nasal vaccines in use in China and India rely on harmless adenoviruses to ferry their instructions into cells, although effectiveness data for these has not been published.

Two other nasal vaccines are finishing human studies.

One, a recombinant vaccine that can be produced cheaply in chicken eggs, the same way many flu vaccines are, is being put through its paces by researchers at Mount Sinai in New York City.

Another, like the German vaccine, uses a live but weakened version of the virus. It’s being developed by a company called Codagenix. Results of those studies, which were carried out in South America and Africa, may come later this year.

The German team says it’s eagerly watching for the Codagenix data.

“They will be very important in order to know where whether this kind of attempt is basically promising or not,” Wyler said.

They have reason to worry. Respiratory infections have proved to be tough targets for inhaled vaccines.

FluMist, a live but weakened form of the flu virus, works reasonably well in children but doesn’t help adults as much. The reason is thought to be that adults already have immune memory for the flu, and when the virus is injected into the nose, the vaccine mostly boosts what’s already there.

Still, some of the most potent vaccines such as the vaccine against measles, mumps and rubella use live attenuated viruses, so it’s a promising approach.

Another consideration is that live vaccines can’t be taken by everyone. People with very compromised immunity are often cautioned against using live vaccines because even these very weakened viruses may be risky for them.

“Although it’s strongly attenuated, it’s still a real virus,” Wyler said, so it would have to be used carefully.

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Chronic stress can affect your health. One activity can help | CNN

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CNN
 — 

These days, many people find it hard to unplug. Inflation, global warming and gun violence are on the rise. Bullies proliferate on social media. The 24/7 news cycle constantly blares distressing news, and people often face difficult personal or professional situations.

About half of Americans said they experienced stress within the past day, according to a Gallup Poll survey from last October, a finding that was consistent for most of 2022. Personal finances and current and political events were major sources of stress for one-third or more of adults, a survey from CNN in partnership with the Kaiser Family Foundation found in October.

Stress isn’t inherently bad, said Richard Scrivener, a personal trainer and product development manager at London’s Trainfitness, an education technology company. Stressing your muscles through weight training, for example, leads to beneficial changes. In addition, short-term stress in healthy people typically isn’t a hazard. “But if stress is continuous, especially in older or unhealthy individuals, the long-term effects of the response to stress may lead to significant health issues,” Scrivener said.

Stress occurs when you face a new, unpredictable or threatening situation, and you don’t know whether you can manage it successfully, said clinical psychologist Dr. Karmel Choi, an assistant professor in the Center for Precision Psychiatry at Harvard Medical School and Massachusetts General Hospital in Boston.

When you’re physically or emotionally stressed, your body snaps into fight-or-flight mode. Cortisol rushes through your system, signaling your body to release glucose. Glucose, in turn, provides energy to your muscles so you are better prepared to fight off a threat or run away. During this cortisol rush, your heart rate may rise, your breathing may become rapid, and you may feel dizzy or nauseated.

If you truly needed to fight or flee a predator, your cortisol levels would drop back down once the conflict was over. When you’re chronically stressed, however, those levels stay elevated.

Remaining in that heightened state is no good since high levels of cortisol can exacerbate health conditions such as cardiovascular disease, diabetes and chronic gastrointestinal problems, according to the Cleveland Clinic. Stress can also cause or contribute to anxiety, irritability, poor sleep, substance abuse, chronic distrust or worry, and more.

Luckily, there are many ways to combat stress. Keep a daily routine, get plenty of sleep, eat healthy foods, and limit your time following the news or engaging in social media, recommends the World Health Organization. It also helps to stay connected with others and to employ calming practices such as meditation and deep breathing. One of the most successful tools, though, is physical activity.

“Exercise is remarkably effective for managing psychological stress,” Choi said. “Exercise doesn’t remove what’s causing the stress, but it can boost mood, reduce tension and improve sleep — all of which are impacted by stress — and ultimately this can support people to approach their challenges in a more balanced way.”

Numerous studies back up the positive effect of exercise on stress. Physical activity, and especially exercise, significantly reduced the symptoms of anxiety in a study published in Advances in Experimental Medicine and Biology, for example. Similarly, a Frontiers in Psychology study of university students found that regularly engaging in low- to moderate-intensity aerobic exercises for six weeks helped alleviate their depressive symptoms and perceived stress.

The reason exercise is so effective in squashing stress is fairly simple. Exercise causes your body to produce more endorphins, which are neurotransmitters that boost your mood. Movement also combats elevated levels of the stress hormone cortisol while improving blood flow.

Aerobic workouts, such as running, dancing and boxing, produce lots of mood-boosting endorphins that relieve stress. But gentler exercise such as walking works, too.

Jessica Honig, a clinical social worker in Phoenixville, Pennsylvania, said exercise empowers her clients because they realize that, through movement, they hold the key to reset and lessen their stress. “It’s also one of the best ways to pause — to break up or revive energy from a spiraling, unproductive mindset,” she said.

What types of exercise are best? While studies show aerobic exercise, such as swimming, running, dancing and boxing, may be the most efficient at getting mood-boosting endorphins rushing through your body, gentler forms of physical activity work, too. Think yoga, strength training and walking. In addition, sometimes less is more.

“What we’re seeing from the data,” Choi said, “is you actually need to move less than the recommended guidelines to see positive effects on mood.”

Since stress loads may change weekly or even daily, Scrivener said it can be helpful to alter your exercise based on your mood. Feeling a cheery 8 on a scale of 1 to 10? Then go for a run. Barely hitting a 3? Opt for something gentle. “This could be a 15-minute stretch followed by a light cycle for 15 minutes, or a 30-minute swim followed by a sauna session,” he said.

Since social engagement is a powerful protective factor for positive mental health, Choi encourages exercising with others. Studies also have shown being out in nature boosts your mood, so exercising outside with friends may provide even more benefits.

Combine exercise and social activity by scheduling regular workouts with a neighbor or joining a class.

Scientists continue to study the link between stress and physical activity. A small study published recently found that combining mindfulness and physical activity can improve sleep and help regulate emotions more than either alone, Choi said. She also warned that people need to be careful not to go overboard on exercise or rely on it exclusively for coping with challenges. Doing so can backfire and create more stress.

It’s also important to remember that humans are geared to release stress physically, no matter their age, said Honig, the social worker. “We see in children the permission to throw their body into pillows to release intense emotions,” she said. “We do not outgrow a need to physically release stress. We merely lose the outlets and social normalization of it.”

Melanie Radzicki McManus is a freelance writer who specializes in hiking, travel and fitness.

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For nearly 50 years, only Black men caddied The Masters. One day, they all but vanished | CNN



CNN
 — 

History never forgets a champion. When you win one of sport’s biggest titles, you become immortal.

Win multiple times and your legacy is even greater. To think of The Masters is to think of Jack Nicklaus, the most successful champion in the major’s history with six wins, and Arnold Palmer, who donned the winner’s green jacket four times in just six years at Augusta National.

And yet for decades, two former champions with a combined nine wins lay buried in unmarked graves.

Willie Peterson caddied Nicklaus’ first five victories, while Nathaniel “Iron Man” Avery was on the bag for all four of Palmer’s triumphs. Avery’s headstone was only installed at Augusta’s Southview Cemetery, in Georgia, in 2017, 32 years after his death. Three years later, a 10-minute drive away at Cedar Grove Cemetery, Peterson – who died in 1999 – received his.

They were just two of Augusta National’s original caddie corps, all of them Black men who, from the inaugural edition of the tournament in 1934, guided golfers around the fabled course.

Every subsequent year for almost half a century, they would play substantial – sometimes pivotal – roles in the destination of the green jacket.

The stories of the original group of Augusta caddies almost always began in the same place: Sand Hills.

Located just three miles from The Masters venue, the historically Black district lay adjacent to Augusta Country Club. There, local kids between 10 and 12 years old could earn a wage carrying the bag for members.

Around 90% of Augusta National’s original caddie corps grew up in the Sand Hill neighborhood, according to Leon Maben, vice president of the board of directors at Augusta’s Lucy Craft Laney Museum of Black History.

Eventually, many would hop across Rae’s Creek to begin work at Augusta National. Or as Ward Clayton, author of “Men on the Bag: The Caddies of Augusta National,” terms it: they “graduated.”

Palmer looks over his shoulder as he sits with a group of caddies during the 1965 Masters.

“They were just looking for a buck,” Clayton told CNN. “They weren’t aiming at the outset to become the greatest caddies in the world, but they did – that’s what they became.

“It wasn’t as much of an age thing as it was just your ability. You had to learn to how to act around adults, how to read greens, how to tell guys what clubs to hit, what their yardage was, and how to read people.

“You had to become a little bit of an amateur psychologist … you had to read them right away, from the first hole.”

There was strong incentive for graduating. A “good bag” at Augusta National would pay up to $5, Maben said, offering $20 for a particularly lucrative day’s labor.

For Jariah “Jerry” Beard, caddie for 1979 Masters champion Fuzzy Zoeller, it meant he could earn as much in a day as his parents could in a week working at the city’s John P. King mill.

If caddying was an education, then Willie “Pappy” Stokes was its headmaster.

Having grown up on the very grounds Augusta National was built on, a 12-year-old Stokes was hired to provide water to workers constructing the club. During bad weather, the youngster closely studied how rain streamed across the terrain, always trickling towards the course’s lowest point: Rae’s Creek.

That realization formed the basis of Stokes’ ability to read greens with near-perfect accuracy, a knowledge he imparted to budding students at Saturday morning “caddie school.”

At just 17-years-old, Stokes helped Henry Picard to the 1938 Masters title. He would retire after helping four different players to five wins at Augusta and having sealed his status as “The Godfather” of caddies.

Stokes watches on as Ben Hogan edges closer to his first Masters title in 1951. Stokes would caddy again for Hogan when he won his second green jacket in 1953.

Stokes’ knowledge trickled down to those that followed, epitomized by Beard in 1979. To this day, Zoeller remains the only golfer to win The Masters on his first attempt, as Beard steered the debutant around Augusta “like a blind man with a seeing-eye dog.”

And they were Zoeller’s words, not Beard’s, relayed by the American in “Loopers: The Caddie’s Long Walk,” a 2019 film co-produced by Clayton.

Maben often joked with Beard, who died in March aged 82, that Zoeller ought to give him his green jacket.

“These guys were ahead of their time,” Maben said. “They knew Augusta National like the back of their hand and were able to direct a golfer without any type of instrument like today’s caddies (use).

“They didn’t have no book to go by or no instrument to say how the wind was blowing that day, anything like that. They were the best at what they did.”

Beard helps Zoeller line up a putt at the 1979 Masters.

And as with “The Godfather,” caddie nicknames were par for the course.

Tommy “Burnt Biscuits” Bennett, on the bag for Tiger Woods’ first Masters in 1995, got his moniker after an attempt as a child to steal biscuits being baked on his Grandma’s wooden stove ended with him badly scalding himself, according to ESPN.

Then there was John H. “Stovepipe” Gordon, Frank “Marble Eye” Stokes, and Matthew “Shorty Mac” Palmer. Avery’s “Iron Man” title had multiple stories as to its origin, according to Clayton, one being that he inadvertently cut off a finger while playing golf with a hatchet and another that he injured a hand playing around with powerful firecrackers.

John H.

But Clayton has a clear favorite in the nickname department: Willie “Cemetery” Perteet, former caddie for President Dwight D. Eisenhower. The story, as recounted by Clayton, goes as follows.

Caddie by day, jazz band drummer in downtown Augusta by night, Perteet was leaving a gig one evening when he was jumped by a gang brandishing knives. The group had been gathered by the caddie’s ex-girlfriend, who was “terrifically hurt” after he had ended the relationship.

Hospitalized by his injuries, Perteet later returned to consciousness – but not in a hospital bed. Instead, he awoke in a refrigerated bay, staring into the horrified eyes of a mortician.

“The doctor evidently gave him too much medication and they thought he was dead,” Clayton explained.

“So all the caddies give him the nickname ‘Dead Man.’ President Eisenhower, right at the outset, said, ‘I don’t really like that title. We’re just going to call you Cemetery.’”

Though those who worked the bag were often close with the golfers they paired with, there was an enduring divide – social, as caddies, and racial, as Black men in America.

Only allowed to play the course on the days Augusta National was closed to members, caddies were “considered a lower class,” despite the respect for their craft, Clayton said. Maben, having spoken to many of the original caddies, agreed.

“That’s during segregation, Jim Crow period, and Black men was downgraded in society, called boy, n***er and all that,” Maben said.

“The way I analyze it, from a lot of the conversations I had, they knew their place at that time in society.”

In 1990, TV executive Ron Townsend became the first Black member admitted to Augusta National, 15 years after Lee Elder had become the first Black golfer to compete at The Masters.

Elder won four times on the PGA Tour.

By the time Townsend arrived, most of Augusta’s original caddie corps had disappeared. For the first 48 years at The Masters, golfers had to employ the services of the club’s caddies, but from 1983 onwards, they could bring their own.

Part of the reason lay in events at the previous year’s tournament, when a miscommunication led to some caddies missing a morning tee time. Several golfers used the incident as leverage in their bid to persuade The Masters to allow players to bring the caddies they employed year-round on the PGA Tour.

Clayton believes the arrival of Tour caddies was a matter of when, not if. “There’s no doubt that there was still a large, large group of excellent caddies at Augusta National. But the depth of those caddie ranks were not as great as what the players wanted,” he said.

“It would just have been nice if it was done in a more seamless manner versus what occurred.”

Caddies old and new at the 1983 Masters.

Regardless of the cause, the impact was profound. The 1983 Masters saw the first White caddies walk the greens at the major, with just 19 Black caddies on the bag, Clayton said.

Peterson was furious after entering the caddy facility to find his trusty No. 1 locker had been taken by an unknowing “Tour caddie.” The matter was quickly resolved, but the outgoing caddies were distraught – a pain felt both emotionally and financially.

“They felt like their jobs were being taken from them,” Clayton explained. “They didn’t have a lot of time for these guys coming in from the outside.”

Within a decade, less than 10 of the original caddie corps remained, he added.

“It was not nice the way they went out,” Carl Jackson, caddie for Ben Crenshaw, told CNN.

“It was a hard thing for all the guys because many of them were really good caddies and had experience about that golf course. At least 25-30 of those pros should not have let their caddies go.”

Yet Jackson’s story at Augusta National would not end for another 40 years.

Like many others, Jackson had begun working at Augusta Country Club before graduating to Augusta National in 1958 to learn his trade under Stokes. He arrived with the nickname “Skillet” because he supposedly couldn’t throw a baseball hard enough to break an egg.

In 1976, he paired with Crenshaw for the first time. For renowned putter “Gentle Ben” and the soft-spoken Jackson, green-reader extraordinaire, the partnership was a match made in heaven. After finishing runner-up on their first outing together, in 1984 Crenshaw clinched a two-shot victory over Watson to seal his maiden major title.

Jackson and Crenshaw formed a formidable partnership.

Crenshaw and Jackson would celebrate a second green jacket in 1995. It marked a hugely emotional victory for the Texan golfer, whose mentor Harvey Penick had died just before the tournament, leaving him in “shambles,” Jackson said.

When Crenshaw tapped home his winning putt, the duo shared a long hug on the green. Almost 20 years later to the day, the pair would repeat the gesture when – after their 39th outing – they retired together at the 2015 Masters.

The pair’s friendship lies at the heart of a forthcoming documentary on Jackson’s life, “Rise Above.”

“That’s how America ought to be,” Jackson says in the film. “The Black man taking care of the White man and the White man taking care of the Black man.’”

For Jackson, the core message of the documentary is about respect.

“If you’re righteous, you’re righteous. If you’re unrighteous, you’re gonna be a hater anyway.”

Jackson and Crenshaw embrace on the 18th green after their final hole together at The Masters.

Clayton will be at Augusta National this week, overseeing content for Masters.com, keeping a close eye on the men in the white jumpsuits and green hats carrying the clubs of those vying for the 2023 green jacket.

He will do so with as comprehensive a knowledge of the history of the club’s caddies as any in attendance. Yet prior to researching his 2004 book, mythic stories of “The Godfather,” “Cemetery,” and Augusta’s original caddie core were just that to him – myths. And that troubled Clayton.

“That was my effort, to tell their stories,” he said. “Because I thought they played a vital, vital role in making that club what it is and also helping golfers win … they deserved their attention.

“A lot of them aren’t with us any longer. That number is diminishing every year and they should be honored or remembered in a way that tells the story of who they are.”

The legacy of The Masters' original caddies lives on at Augusta National.

Preserving and spreading those stories is an ongoing mission. Clayton helped get the headstones for Avery and Peterson, with Palmer and Nicklaus also involved for their respective caddies.

This year, the Lucy Craft Laney Museum will put the legacy of Augusta’s Black caddies – quite literally – center stage.

Twice a month at the museum, supplementing its regular tours, the “Men on the Bag Experience” will see the stories of three original Augusta caddies – Stokes, Perteet, and Peterson – acted out in a play.

At the end of each performance, at least two original caddies – or “living legends” as Maben refers to them – will emerge from the audience to host an on-stage Q&A. Each will be immortalized in a sports trading card, stylized with their picture, story, and stats, to be signed and distributed to patrons as they leave the show.

Maben rarely calls them caddies. It’s almost always “living legends,” “superstars” or, most commonly of all, “champions.”

And history never forgets a champion.

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Why do Masters champions win a green jacket? | CNN



CNN
 — 

Golfers fall asleep dreaming of securing theirs, Bubba Watson was moved to tears simply reminiscing over his, and one fan was willing to shell out over $680,000 just to own one.

Augusta National’s green jacket – an exclusive prize for Masters champions – is golf’s most coveted fashion statement, and one of sport’s most iconic pieces of clothing.

Sure, the prestige of winning one of the four majors in men’s golf and the trophy, not to mention the prize money, are welcome rewards, but the storied history of the Georgia club’s green member’s jacket earned it a unique reputation among those that pursue it.

The story of Augusta’s green jacket began some 3,900 miles across the Atlantic, in the town of Hoylake in northwest England.

Ahead of hosting its sixth British Open Championship in 1930, Royal Liverpool Golf Club held a players’ reception. In attendance was the most celebrated amateur golfer of the era, American Bobby Jones.

Over dinner, Jones proceeded to pepper former club captain Kenneth Stoker with questions on his red coat, the formal kit of Royal Liverpool captains.

“Mr. Jones, if you’re so fascinated by this, I will give you my coat if you win our Championship this week,” challenged Stoker – according to a CNN interview with club historian Joe Pinnington in 2014.

Naturally, Jones made short work of the wager, clinching the 11th of his 13 career major victories and returning to the US with a trophy – and a red blazer.

After becoming the first and only golfer to complete the original grand slam (Amateur Championship, Open Championship, US Open, US Amateur) months later, Jones stunned the sporting world by announcing his retirement from competitive golf at just 28 years old.

Harboring a passion for course design, Jones had other plans in mind. In 1934, his newly founded Augusta National hosted the first incarnation of The Masters.

Three years later, Augusta members started wearing green jackets to make themselves identifiable to patrons. In 1949 it was decided that year’s victor, Sam Snead, and all the previous champions, would be issued with their own version too.

The heavily bunkered appraoch to the par 5 3rd hole on the Royal Liverpool Golf Course, on June 10, 2004 in Hoylake, England.

How Royal Liverpool Golf Club inspired the Masters green jacket

The green jacket wasn’t a smash hit from the start, though. Originally produced by New York’s Brooks Uniform Company, Augusta members complained that the jackets were overly thick and uncomfortable in hot conditions, leading to a swift change of manufacturer, according to the PGA Tour.

Since 1967, Hamilton Tailoring Company of Cincinnati has held responsibility for making the jacket, the color of which is officially classified as “Pantone 342.”

Production is a month-long process that sees the owners name stitched inside and Augusta National logos emblazoned on both the chest pocket and brass buttons.

As a result, the jacket slipped onto the shoulders of winners on Sunday is simply for presentation, with the real one handed over later.

Yet newly crowned champions can’t simply walk away and find a lifetime spot for their new prize in their wardrobe – terms and conditions apply.

For starters, the jackets cannot be removed from – and can only be worn on – the grounds of Augusta National, though winners are permitted to take theirs home for a year on the condition they bring it back at the next edition of the tournament to hang in the Champions Locker Room.

When the defending champion returns a year later, they – along with a host of former victors – will don their jacket for the Masters Champions Dinner. The reigning winner decides the menu, with Scottie Scheffler serving up cheeseburger sliders, ribeye steak, and chocolate chip cookies for this year’s meal. Their final responsibility is to help the new winner slip into his new jacket during a ceremonial “passing of the torch” presentation outside Butler Cabin.

But what if a champion successfully defends his title? That was a question Masters co-founders Jones and Clifford Roberts hurriedly answered in 1966 when Jack Nicklaus became the first back-to-back champion at Augusta.

The pair decided that “The Golden Bear” should put the jacket on himself, and in the two repeat occasions since – Nick Faldo in 1990 and Tiger Woods in 2002 – the Masters chairman assumed responsibility for helping the golfers into their jackets.

Faldo helps 1997 Masters champion Woods into his green jacket.

There is one infamous exception to the rule of returning your jacket.

When Gary Player became the first international golfer to win The Masters in 1961, he jetted home to South Africa with his green jacket tucked away in his luggage. The following year, when he was defeated by Arnold Palmer in a playoff, he didn’t return it.

“I didn’t know you were supposed to leave it there,” said Player. “Next thing you know, there was a call from Mr. Roberts. And I said, ‘Well, Mr. Roberts, if you want it, why don’t you come and fetch it?’”

Roberts saw the funny side, Player added, and allowed the South African to keep it on the condition that he didn’t wear it in public. “The Black Knight” would go on to win two further Masters in 1974 and 1978.

Player was an honorary starter at the 2017 tournament.

Given how hard it is for the game’s finest to get their hands on a green jacket, it’s borderline impossible for non-golfers to do the same – but that hasn’t stopped a select few from trying.

In 2013, the jacket owned by Horton Smith, winner of the inaugural Masters in 1934, sold for $682,229 to an unnamed buyer at an auction hosted by Green Jacket Auctions.

Smith won The Masters in 1934 and 1936.

In 2017, Augusta National filed a lawsuit to stop the memorabilia company from auctioning another winner’s green jacket, as well as two members’ green jackets, according to the Associated Press.

The champion’s jacket was purported to have belonged to 1966 winner Byron Nelson. His blazer was marked in an inventory check at Augusta in 2009 before going missing, the lawsuit said.

In January 2019, Augusta National and Green Jacket Auctions agreed to drop their legal dispute, according to the Augusta Chronicle.

One jacket auctioned by Green Jacket Auctions was reported to have been first discovered in a Toronto thrift shop. Purchased for a measly $5, the jacket, whose original owner was undisclosed, was sold at auction for $139,349 in April 2017.

From letting friends – and even newborn children – try it on for size, to donning it for barbeques, Masters champions have found various uses for their green jackets during their limited-time home ownership.

“I didn’t take it for granted whatsoever,” 2015 champion Jordan Spieth told reporters upon his return to Augusta the following year.

“I think that I could have taken advantage of having it in my possession more than I did, but you learn and next time I’ll do a little bit better.

“Some of my favorite memories were certainly back home, having a bunch of my friends over and just having the jacket on while you’re grilling out … it was certainly a lot of fun and I don’t want to have to give it back.”

Spieth settles into his green jacket after victory in 2015.

For others, the satisfaction of turning rivals green with envy is enough.

“It’s a great way to give the other guys grief, give them a little jab here or there,” said Phil Mickelson, champion in 2004, 2006, and 2010.

Charl Schwartzel, who mounted a stunning final day charge to seal victory in 2011, said: “To have it with you and to see the people’s faces when you walk in … they always take a second look like, ‘that’s the jacket!’”

Zach Johnson described dressing his four-month-old son in his 2007 winner’s jacket for a picture session, following in the footsteps of Bubba Watson, who did the same with his adopted son after triumph in 2012.

“I wrapped Caleb up in it, that was the only thing I did with it,” a tearful Watson told reporters in 2013.

“Out of respect and honor for Augusta National and one of the greatest clubs we have, one of the greatest tournaments … I didn’t do any of my funny antics that I normally would do.”

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The haunting Masters meltdown that changed Rory McIlroy’s career | CNN



CNN
 — 

Slumped on his club, head buried in his arm, Rory McIlroy looked on the verge of tears.

The then-21-year-old had just watched his ball sink into the waters of Rae’s Creek at Augusta National and with it, his dream of winning The Masters, a dream that had looked so tantalizingly close mere hours earlier.

As a four-time major winner and one of the most decorated names in the sport’s history, few players would turn down the chance to swap places with McIlroy heading into Augusta this week.

Yet on Sunday afternoon of April 10, 2011, not a golfer in the world would have wished to be in the Northern Irishman’s shoes.

A fresh-faced, mop-headed McIlroy had touched down in Georgia for the first major of the season with a reputation as the leading light of the next generation of stars.

An excellent 2010 had marked his best season since turning pro three years earlier, highlighted by a first PGA Tour win at the Quail Hollow Championship and a crucial contribution to Team Europe’s triumph at the Ryder Cup.

Yet despite a pair of impressive top-three finishes at the Open and PGA Championship respectively, a disappointing missed cut at The Masters – his first at a major – served as ominous foreshadowing.

McIlroy shot 74 and 77 to fall four strokes short of the cut line at seven-over par, a performance that concerned him enough to take a brief sabbatical from competition.

But one year on in 2011, any lingering Masters demons looked to have been exorcised as McIlroy flew round the Augusta fairways.

Having opened with a bogey-free seven-under 65 – the first time he had ever shot in the 60s at the major – McIlroy pulled ahead from Spanish first round co-leader Alvaro Quirós with a second round 69.

It sent him into the weekend holding a two-shot cushion over Australia’s Jason Day, with Tiger Woods a further stroke behind and back in the hunt for a 15th major after a surging second round 66.

And yet the 21-year-old leader looked perfectly at ease with having a target on his back. Even after a tentative start to the third round, McIlroy rallied with three birdies across the closing six holes to stretch his lead to four strokes heading into Sunday.

McIlroy drives from the 16th tee during his second round.

The youngster was out on his own ahead of a bunched chasing pack comprising Day, Ángel Cabrera, K.J. Choi and Charl Schwartzel. After 54 holes, McIlroy had shot just three bogeys.

“It’s a great position to be in … I’m finally feeling comfortable on this golf course,” McIlroy told reporters.

“I’m not getting ahead of myself, I know how leads can dwindle away very quickly. I have to go out there, not take anything for granted and go out and play as hard as I’ve played the last three days. If I can do that, hopefully things will go my way.

“We’ll see what happens tomorrow because four shots on this golf course isn’t that much.”

McIlroy finished his third round with a four shot lead.

The truth can hurt, and McIlroy was about to prove his assessment of Augusta to be true in the most excruciating way imaginable.

His fourth bogey of the week arrived immediately. Having admitted to expecting some nerves at the first tee, McIlroy sparked a booming opening drive down the fairway, only to miss his putt from five feet.

Three consecutive pars steadied the ship, but Schwartzel had the wind in his sails. A blistering birdie, par, eagle start had seen him draw level at the summit after his third hole.

A subsequent bogey from the South African slowed his charge, as McIlroy clung onto a one-shot lead at the turn from Schwartzel, Cabrera, Choi, and a rampaging Woods, who shot five birdies and an eagle across the front nine to send Augusta into a frenzy.

Despite his dwindling advantage and the raucous Tiger-mania din ahead of him, McIlroy had responded well to another bogey at the 5th hole, draining a brilliant 20-foot putt at the 7th to restore his lead.

The fist pump that followed marked the high-water point of McIlroy’s round, as a sliding start accelerated into full-blown free-fall at the par-four 10th hole.

His tee shot went careening into a tree, ricocheting to settle between the white cabins that separate the main course from the adjacent par-three course. It offered viewers a glimpse at a part of Augusta rarely seen on broadcast, followed by pictures of McIlroy anxiously peering out from behind a tree to track his follow-up shot.

McIlroy watches his shot after his initial drive from the 10th tee put him close to Augusta's cabins.

Though his initial escape was successful, yet another collision with a tree and a two-putt on the green saw a stunned McIlroy eventually tap in for a triple bogey. Having led the field one hole and seven shots earlier, he arrived at the 11th tee in seventh.

By the time his tee drive at the 13th plopped into the creek, all thoughts of who might be the recipient of the green jacket had long-since switched away from the anguished youngster. It had taken him seven putts to navigate the previous two greens, as a bogey and a double bogey dropped him to five-under – the score he had held after just 11 holes of the tournament.

Mercifully, the last five holes passed without major incident. A missed putt for birdie from five feet at the final hole summed up McIlroy’s day, though he was given a rousing reception as he left the green.

Mere minutes earlier, the same crowd had erupted as Schwartzel sunk his fourth consecutive birdie to seal his first major title. After starting the day four shots adrift of McIlroy, the South African finished 10 shots ahead of him, and two ahead of second-placed Australian duo Jason Day and Adam Scott.

McIlroy’s eight-over 80 marked the highest score of the round. Having headlined the leaderboard for most of the week, he finished tied-15th.

McIroy was applauded off the 18th green by the Augusta crowd after finishing his final round.

Tears would flow during a phone call with his parents the following morning, but at his press conference, McIlroy was upbeat.

“I’m very disappointed at the minute, and I’m sure I will be for the next few days, but I’ll get over it,” he said.

“I was leading this golf tournament with nine holes to go, and I just unraveled … It’s a Sunday at a major, what it can do.

“This is my first experience at it, and hopefully the next time I’m in this position I’ll be able to handle it a little better. I didn’t handle it particularly well today obviously, but it was a character-building day … I’ll come out stronger for it.”

Once again, McIlroy would be proven right.

Just eight weeks later in June, McIlroy rampaged to an eight-shot victory at the US Open. Records tumbled in his wake at Congressional, as he shot a tournament record 16-under 268 to become the youngest major winner since Tiger Woods at The Masters in 1997.

McIlroy celebrated a historic triumph at the US Open just two months after his Masters nightmare.

The historic victory kickstarted a golden era for McIlroy. After coasting to another eight-shot win at the PGA Championship in 2012, McIlroy became only the third golfer since 1934 to win three majors by the age of 25 with triumph at the 2014 Open Championship.

Before the year was out, he would add his fourth major title with another PGA Championship win.

And much of it was owed to that fateful afternoon at Augusta. In an interview with the BBC in 2015, McIlroy dubbed it “the most important day” of his career.

“If I had not had the whole unravelling, if I had just made a couple of bogeys coming down the stretch and lost by one, I would not have learned as much.

“Luckily, it did not take me long to get into a position like that again when I was leading a major and I was able to get over the line quite comfortably. It was a huge learning curve for me and I needed it, and thankfully I have been able to move on to bigger and better things.

“Looking back on what happened in 2011, it doesn’t seem as bad when you have four majors on your mantelpiece.”

A two-stroke victory at Royal Liverpool saw McIlroy clinch the Open Championship in 2014.

McIlroy’s contentment came with a caveat: it would be “unthinkable” if he did not win The Masters in his career.

Yet as he prepares for his 15th appearance at Augusta National this week, a green jacket remains an elusive missing item from his wardrobe.

Despite seven top-10 finishes in his past 10 Masters outings, the trophy remains the only thing separating McIlroy from joining the ranks of golf immortals to have completed golf’s career grand slam of all four majors in the modern era: Gene Sarazen, Ben Hogan, Gary Player, Jack Nicklaus, and Tiger Woods.

The Masters is the only major title to elude McIlroy.

A runner-up finish to Scottie Scheffler last year marked McIlroy’s best finish at Augusta, yet arguably 2011 remains the closest he has ever been to victory. A slow start in 2022 meant McIlroy had begun Sunday’s deciding round 10 shots adrift of the American, who teed off for his final hole with a five-shot lead despite McIlroy’s brilliant 64 finish.

At 33 years old, time is still on his side. Though 2022 extended his major drought to eight years, it featured arguably his best golf since that golden season in 2014.

And as McIlroy knows better than most, things can change quickly at Augusta National.

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FDA approves first over-the-counter version of opioid overdose antidote Narcan | CNN



CNN
 — 

With drug overdose deaths continuing to hover near record levels, the US Food and Drug Administration on Wednesday approved for the first time an over-the-counter version of the opioid overdose antidote Narcan.

“The FDA remains committed to addressing the evolving complexities of the overdose crisis. As part of this work, the agency has used its regulatory authority to facilitate greater access to naloxone by encouraging the development of and approving an over-the-counter naloxone product to address the dire public health need,” FDA Commissioner Dr. Robert Califf said in a statement.

“Today’s approval of OTC naloxone nasal spray will help improve access to naloxone, increase the number of locations where it’s available and help reduce opioid overdose deaths throughout the country. We encourage the manufacturer to make accessibility to the product a priority by making it available as soon as possible and at an affordable price.”

Dr. Rahul Gupta, director of the White House’s Office of National Drug Control Policy, said accessibility is key to ensuring that the Narcan nasal spray saves lives.

“It’s really important that we continue to do everything possible in our power to make this life-saving drug available to anyone and everyone across the country,” Gupta said.

The White House drug czar said businesses, such as restaraunts and banks, and schools will be encouraged to purchase over-the-counter naloxone.

“We will encourage businesses, restaurants, banks, construction sites, schools, others to think about this – think about it as a smoke alarm or a defibrillator, to make it as easily accessible, because it’s not just you. It could be your neighbor, it could be your family, your friend, a person at work or school who might need it, ” Gupta said.

The nasal spray will come in a package of two 4-milligram doses, in case the person overdosing does not respond to the first dose. However, the drug’s maker, Emergent BioSolutions, says most overdoses can be reversed with a single dose. The product could be given to anyone, even children and babies.

The nasal spray is expected to be available for purchase in stores and online by late summer, Emergent said Wednesday.

More than a million people have died of drug overdoses in the two decades since the US Centers for Disease Control and Prevention began collecting that data. Many of those deaths were due to opioids. Deaths from opioid overdoses rose more than 17% in just one year, from about 69,000 in 2020 to about 81,020 in 2021, the CDC found.

Opioid deaths are the leading cause of accidental death in the US. Most are among adults, but children are also dying, largely after ingesting synthetic opioids such as fentanyl. Between 1999 and 2016, nearly 9,000 children and adolescents died of opioid poisoning, with the highest annual rates among adolescents 15 to 19, the CDC found.

Nearly every state in the US has standing orders that allow pharmacists or other qualified organizations to provide the medication without a personal prescription to people who are at risk of an overdose or are helping someone at risk, but making it available over the counter can make it easier for people to access the opioid antidote.

Research shows that wider availability could save lives as opioid overdoses have skyrocketed in recent years – much of it due to synthetic opioids like illicitly made fentanyl.

Emergent President and CEO Robert Kramer hailed the FDA’s decision as a “historic milestone.”

“We are dedicated to improving public health and assisting those working hard to end the opioid crisis – so now with leaders across government, retail and advocacy groups, we must work together to continue increasing access and availability, as well as educate the public on the risks of opioid overdoses and the value of being prepared with Narcan Nasal Spray to help save a life,” Kramer said in a statement.

Narcan works by blocking the effects of opioids on the brain and restoring breathing. For the most effectiveness, it must be given as soon as signs of overdose appear.

The drug works on someone only if there are opioids in their system. It won’t work on any other type of drug overdose, but it won’t have adverse effects if given to someone who hasn’t taken opioids.

Naloxone reverses an overdose for up to about 90 minutes, but opioids can stay in the system for longer, so it’s still important to call 911 after giving the drug.

People given naloxone should be watched carefully until medical help arrives and monitored for another two hours.

About 1.2 million doses of naloxone were dispensed by retail pharmacies in 2021, according to data published by the American Medical Association – nearly nine times more than were dispensed five years earlier.

Emergent said it does not have information on how much OTC Narcan will cost.

Harm reduction experts say the price of naloxone has inhibited its accessibility to people who need it most. And although the cost will probably drop as it becomes available over the counter, they say it will probably still be out of reach for many.

“We’re not going to be able to ramp up naloxone distribution in a game-changing way until we get a better handle on the price,” said Nabarun Dasgupta, a scientist at the University of North Carolina’s Injury Prevention Research Center who studies drugs and infectious diseases. “There’s the promise on paper versus on the street, and it’s going to come down to the dollars and cents.”

Separate changes to grant funding by both the CDC and the Substance Abuse and Mental Health Services Administration will make it easier for states and local health departments to buy naloxone, he said.

Gupta said the Biden administration is asking the drugmakers to keep the price of the antidote low.

“That’s one of the things that the president has been very clear: that we’ve got to make sure that these life-saving medications, as well as treatment, is accessible across no matter where you live, rural or urban, rich or poor. We want to make sure this is accessible across broad swaths of people,” he said.

However, experts said the most meaningful work in the fight against the devastating outcomes of the drug overdose epidemic will come with ongoing emphasis on treatment for opioid use disorder and other harm-reduction strategies.

“While enabling people to access quality treatment for substance use disorders is critical, we must also acknowledge that people need to survive in order to have that choice,” said Dr. Nora Volkow, director of the National Institute on Drug Abuse, said in January.

Caleb Banta-Green, principal research scientist at the University of Washington’s Addictions, Drug & Alcohol Institute, has described naloxone as the “gateway drug” to a conversation about what substance use disorder is.

“It’s a conversation starter. It’s life-saving for the individual. It’s not a game-changer at the population level,” he said. “We need to do more. And we need to use treatment medications – methadone and buprenorphine – which are far higher overdose preventive approaches.”

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What someone with an eating disorder wishes you knew | CNN

Editor’s Note: This story is part of an occasional series covering disordered eating and diet culture.



CNN
 — 

Getting diagnosed with an eating disorder happened by accident to Emily Boring.

She went to her university’s mental health office to talk about anxiety she was feeling, and through conversations learned that her behaviors with food were classified as an eating disorder, she said.

Now 27 and a graduate student at the Yale Divinity School in New Haven, Connecticut, her journey of recovery and relapse has taught her a lot about how to care for herself and others, she said.

During Eating Disorders Awareness Week in late February, Boring spoke to CNN about the misunderstanding, shame and stigma around eating disorders so they can be better understood.

This conversation has been edited and condensed for clarity.

CNN: What do you want people to know about disordered eating and eating disorders?

Emily Boring: I wish people knew that it is everywhere. The vast majority of people will experience some kind of disordered relationship to food in their bodies, simply because of the culture we live in.

What I would say first and foremost is disordered eating — and this also applies to formal eating disorders — don’t look a certain way. They affect everyone regardless of gender, race, ethnicity, age, socioeconomic status. Disordered eating and eating disorders do not come with a “thin” or underweight body.

CNN: How do you understand eating disorders and treatment?

Boring: Eating disorders are now classified as metabo-psychiatric illnesses — metabolism referring to the way the body processes energy, and then the psychiatric portion related to brain and behavior.

This has confirmed the experience of people with eating disorders. We for decades — and clinicians also — have noticed that eating disorders tend to be activated when someone falls into energy deficit or doesn’t take in enough calories to support their body.

Eating disorders are not shameful. They’re not a choice, and they’re not a failure. There’s still some lingering stigma around the thought that eating disorders are something that you choose. I would add on to that: if someone is on the precipice of realizing they have an eating disorder or receiving that diagnosis from someone else, I would stress the importance of early intervention. And I would say that the first step to recovery is finding a really good eating disorder team (including a) therapist, dietician and a doctor.

CNN: How should loved ones talk to people in recovery from eating disorders?

Boring: I do speak mostly from my own experience, but I’ve also mentored quite a few teenagers during this process. I’ve learned the hard way what isn’t helpful to say to them, and I’ve also been the recipient (of unhelpful comments).

To the extent that you can, avoid comments and actions that we associate with diet culture. Especially in this country, the way that we privilege fitness in popular culture is antithetical to recovery. Diet culture oftentimes hides beneath the banner of healthism — that’s basically the belief that there is a standard of fitness and able-bodiedness that everyone can attain if we just work hard.

There’s a whole body of literature — scientific literature showing that health and weight are not all causally related. So higher weight doesn’t necessarily equal poor health outcome.

CNN: What do you mean when you say not to use “the eating disorder’s own voice” to talk back to it?

Boring: Let’s say I show up in a doctor’s office, and I’m afraid of what’s happening to my body. I’m afraid I’m going to gain weight. And a clinician may say well meaningly, “Don’t worry, your body’s not going to change that much. Your weight doesn’t have to go higher.”

Regardless of the factualness of that statement or not, that’s just playing right into the eating disorder’s belief. It’s so easy to try to reassure (your loved one) using the eating disorder’s own language, and I found that that just really doesn’t work in the long run.

CNN: What are ways to talk to people without using the voice of the eating disorder?

Boring: Some questions that I encourage folks to ask themselves are things like, “Is what I’m about to say implying that some bodies are better than other bodies? Or that some foods have greater or lesser moral worth?” Also try to avoid mentioning anything with numbers, whether that is weight or calories or number of hours exercising per week.

Don’t assume someone’s inner state based on how they do or don’t look on the outside. As much as people can, step back and ask questions, instead of making an assumption.

An example: “I see that you’re improving in these behaviors, like we set the goal of last week. How’s that feeling to you? How was your mind reacting?” So that process of gentle inquiry rather than statements and assumptions is really key.

CNN: What do people need to know about relapse?

Boring: That it is not a failure, and that doesn’t have to lead you back to the worst of illness that you’ve ever experienced. You can catch it early, and you can turn things around.

What I wish that I had known about relapse is that it happens more quickly and more sudden and all consumingly than I thought.

If you’re someone who has the genes for an eating disorder — whether that’s anorexia, bulimia, binge-eating disorder, any (disease) on the spectrum — you’re probably always going to have to be careful and vigilant about maintaining nutrition, eating an abundance and variety of foods, insulating yourself from diet culture. Because it can happen fast — a few days of restriction, a few lost pounds and all of a sudden, you’re back fully in the eating disorder.

And I would also say that relapse is a learning opportunity. It doesn’t always feel like that in the moment, but the times that I’ve relapsed, I look back and I realized in each instance, I’ve discovered something about what recovery means to me.

I guess that’s just a way to say, be gentle with yourself and be open-minded that yes, relapse is a crisis, and you need to do everything you can to get out of it. But also, it’s not a failure and it’s not a sign that you’ll be struggling with this forever.

CNN: What have you learned about recovery?

Boring: When I first started recovering, people — mostly clinicians, but also on some of the books and blogs that I’d read from people who’ve recovered — frame recovery, mostly in terms of absence. When you’re recovered, you won’t have these troubling symptoms anymore, or you won’t spend so much time thinking about food in your body.

In reality, what it’s like to be recovered is completely about presence. It is an ability to be present to relationships around you to the things that you’re interested in. It’s also just a physical presence of awareness of your own body, ability to perceive sensations, ability to eventually listen to your body’s cues of hunger and fullness.

The eating disorder is completely gray, and it feels like I’m kind of dragging myself through the days. … When I’m recovered, the world comes back into color again.

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Colorectal cancer is rising among younger adults and scientists are racing to uncover why | CNN



CNN
 — 

Nikki Lawson received the shock of her life at age 35.

A couple of years ago, she noticed that her stomach often felt irritable, and she would get sudden urges to use the restroom, sometimes with blood in her stool. She even went to the hospital one day when her symptoms were severe, she said, and she was told it might be a stomach ulcer before being sent home.

“That was around the time when Chadwick Boseman, the actor, passed away. I remember watching him on the news and having the same symptoms,” Lawson said of the “Black Panther” star who died of colon cancer at age 43 in August 2020.

“But at that time, I was not thinking ‘this is something that I’m going through,’ ” she said.

Instead, Lawson thought changing her diet would help. She stopped eating certain red meats and ate more fruits and vegetables. She began losing a lot of weight, which she thought was the result of her new diet.

“But then I went for a physical,” Lawson said.

Her primary care physician recommended that she see a gastroenterologist immediately because she had low iron levels.

“When I went and I saw my gastro, she said, ‘I’m sorry, I have bad news. We see something. We sent it off to get testing. It looks like it is cancer.’ My whole world just kind of blanked out,” Lawson said. “I was 35, healthy, going about my day, raising my daughter, and to get a diagnosis like this, I was just so shocked.”

Lawson, who was diagnosed with stage III rectal cancer, is among a growing group of colon and rectal cancer patients in the United States who are diagnosed at a young age.

The share of colorectal cancer diagnoses among adults younger than 55 in the US has been rising since the 1990s, and no one knows why.

Researchers at Dana-Farber Cancer Institute are calling for more work to be done to understand, prevent and treat colorectal cancer at younger ages.

In a paper published last week in the journal Science, the researchers, Dr. Marios Giannakis and Dr. Kimmie Ng, outlined a way for scientists to accelerate their investigations into the puzzling rise of colorectal cancer among younger ages, calling for more specialized research centers to focus on younger patients with the disease and for diverse populations to be included in studies on early-onset colorectal cancer.

Their hope is that this work will help improve outcomes for young colorectal cancer patients like Lawson.

Among younger adults, ages 20 to 49, colorectal cancer is estimated to become the leading cause of cancer-related deaths in the United States by 2030.

Lawson, now 36 and living in Palm Bay, Florida, with her 5-year-old daughter, is in remission and cancer-free.

The former middle school teacher had several surgeries and received radiation therapy and chemotherapy to treat her cancer. She is now being monitored closely by her doctors.

For other young people with colorectal cancer, “my words of hope would be to just stay strong. Just find that courage within yourself to say, ‘You know what, I’m going to fight this.’ And I just looked within myself,” Lawson said.

“I also have a very supportive family system, so they were definitely there for me. But it was very emotional,” she said of her cancer treatments.

“I remember crying through chemotherapy sessions and the medicine making you so weak, and my daughter was 4, and having to be strong for her,” she said. “My advice to any young person: If you see symptoms or you see something’s not right and you’re losing a lot of weight and not really trying to, go to see a doctor.”

Signs and symptoms of colorectal cancer include changes in bowel habits, rectal bleeding or blood in the stool, cramping or abdominal pain, weakness and fatigue, and weight loss.

A report released this month by the American Cancer Society shows that the proportion of colorectal cancer cases among adults younger than 55 increased from 11% in 1995 to 20% in 2019. Yet the factors driving that rise remain a mystery.

There’s probably more than just one cause, said Lawson’s surgeon, Dr. Steven Lee-Kong, chief of colorectal surgery at Hackensack University Medical Center in New Jersey.

He has noticed an increase in colorectal cancer patients in their 40s and 30s within his own practice. His youngest patient was 21 when she was diagnosed with rectal cancer.

“There is a phenomenon of decreasing overall colorectal cancer rates in the population in general, we think because of the increase in screening for particularly for older adults,” Lee-Kong said. “But that doesn’t really account for the overall increase in the number of patients younger than, say, 50 and 45 that are developing cancer.”

Some of the factors known to raise anyone’s risk of colorectal cancer are having a family history of the disease, having a certain genetic mutation, drinking too much alcohol, smoking cigarettes or being obese.

“They were established as risk factors in older cohorts of patients, but they do seem to be also associated with early-onset disease, and those are things like excess body weight, lack of physical activity, high consumption of processed meat and red meat, very high alcohol consumption,” said Rebecca Siegel, a cancer epidemiologist and senior scientific director of surveillance research at the American Cancer Society, who was lead author of this month’s report.

“But the data don’t support these specific factors as solely driving the trend,” she said. “So if you have excess body weight, you are at a higher risk of colorectal cancer in your 40s than someone who is average weight. That is true. But the excess risk is pretty small. So again, that is probably not what’s driving this increase, and it’s another reason to think that there’s something else going on.”

Many people who are being diagnosed at a younger age were not obese, including some high-profile cases, such as Broadway actor Quentin Oliver Lee, who died last year at 34 after being diagnosed with stage IV colon cancer.

“Anecdotally, in conferences that I’ve attended, that is the word on the street: that most of these patients are very healthy. They’re not obese; they’re very active,” Siegel said, which adds to the mystery.

“We know that excess weight increases your risk, and we know that we’ve had a big increase in body weight in this country,” she said. “And that is contributing to more cancer for a lot of cancers and also for colorectal cancer. But does it explain this trend that we’re seeing, this steep increase? No, it doesn’t.”

Yet scientists remain divided when it comes to just how much of a role those known risk factors – especially obesity – play in the rise of colorectal cancer among adults younger than 55.

Even though the cause of the rise of colorectal cancer in younger adults is “still not very well understood,” Dr. Subhankar Chakraborty argues that dietary and lifestyle factors could be playing larger roles than some would think.

“We know that smoking, alcohol, lack of physical activity, being overweight or obese, increased consumption of red meat – so basically, dietary factors and environmental and lifestyle factors – are likely playing a big role,” said Chakraborty, a gastroenterologist with The Ohio State University Comprehensive Cancer Center.

“There are also some other factors, such as the growing incidence of inflammatory bowel disease, that may also be playing a role, and I think the biggest factors is most likely the diet, the lifestyle and the environmental factors,” he said.

It has been difficult to pinpoint causes of the rise of cases in younger ages because, if someone has a polyp in their colon for example, it can take 10 to 15 years to develop into cancer, he says.

“During that, all the way from a polyp to the cancer stage, the person is exposed to a variety of things in their life. And to really pinpoint what is going on, we would need to follow specific individuals over time to really understand their dietary patterns, medications and weight changes,” Chakraborty said. “So that makes it really hard, because of the time that cancer actually takes to develop.”

Some researchers have been investigating ways in which the rise in colorectal cancer among younger adults may be connected to increases in childhood obesity in the US.

“The rise in young-onset colorectal cancer correlates with a doubling of the prevalence of childhood obesity over the last 30 years, now affecting 20% of those under age 20,” Dr. William Karnes, a gastroenterologist and director of high-risk colorectal cancer services at the UCI Health Digestive Health Institute in California, said in an email.

“However, other factors may exist,” he said, adding that he has noticed “an increasing frequency of being shocked” by discoveries of colorectal cancer in his younger patients.

There could be correlations between obesity in younger adults, the foods they eat and the increase in colorectal cancers for the young adult population, said Dr. Shane Dormady, a medical oncologist from El Camino Health in California who treats colorectal cancer patients.

“I think younger people are on average consuming less healthy food – fast food, processed snacks, processed sugars – and I think that those foods also contain higher concentrations of carcinogens and mutagens, in addition to the fact that they are very fattening,” Dormady said.

“It’s well-publicized that child, adolescent, young adult obesity is rampant, if not epidemic, in our country,” he said. “And whenever a person is at an unhealthy weight, especially at a young age, which is when the cells are most susceptible to DNA damage, it really starts the ball rolling in the wrong direction.”

Yet at the Center for Young Onset Colorectal and Gastrointestinal Cancers at Memorial Sloan Kettering Cancer Center, researchers and physicians are not seeing a definite correlation between the rise in colorectal cancer among their younger adult patients and a rise in obesity, according to Dr. Robin Mendelsohn, gastroenterologist and co-director of the center, where scientists and doctors continue to work around the clock to solve this mystery.

“When we looked at our patients, the majority were more likely to be overweight and obese, but when we compare them to a national cohort without cancer, they’re actually less likely to be overweight and obese,” she said. “And anecdotally, a lot of the patients that we see are young and fit and don’t really fit the obesity profile.”

That leaves many oncologists scratching their heads.

Some scientists are also exploring whether genetic mutations that can raise someone’s risk for colorectal cancer have played a role in the rise of cases among younger adults – but the majority of these patients do not have them.

Karnes, of UCI Health, said “it is unlikely” that there has been an increase in the genetic mutations that raise the risk of colorectal cancer, “although, as expected, the percentage of colorectal cancers caused by such mutations, e.g., Lynch syndrome, is more common in people with young-onset colorectal cancer.”

Lynch syndrome is the most common cause of hereditary colorectal cancer, causing about 4,200 cases in the US per year. People with Lynch syndrome are more likely to get cancers at a younger age, before 50.

“In my practice and in the medical community, the oncologic community, I don’t think there’s any proof that genetic syndromes and gene mutations that patients are born with are becoming more frequent,” El Camino Health’s Dormady said. “I don’t think the inherent frequency of those mutations is going up.”

The tumors of younger colorectal cancer patients are very similar to those of older ones, said Mendelsohn at Memorial Sloan Kettering Cancer Center.

“So then, the question is, if they’re biologically the same, why are we seeing this increasingly in younger people?” she said. “About 20% may have a genetic mutation, so the majority of patients do not have a family history or genetic predisposition.”

Therefore, Mendelsohn added, “it’s likely some kind of exposure, whether it be diet, medication, changing microbiome,” that is driving the rise in colorectal cancers in younger adults.

That rise “has been something that’s been on our radar, and it has been increasing since the 1990s,” Mendelsohn said. “And even though it is increasing, the numbers are still small. So it’s still a small population.”

Dormady, at El Camino Health, said he now sees more colorectal cancer patients in their early to mid-50s than he did 20 years ago, and he wonders whether it might be a result of colorectal cancer screening being easier to access and better at detecting cancers.

“The first thing to consider is that some of our diagnostic modalities are becoming better,” he said, especially because there are now many at-home colorectal cancer testing kits. Also, in 2021, the US Preventive Services Task Force lowered the recommended age to start screening for colon and rectal cancers from 50 to 45.

“I think you have a subset of patients who are being screened earlier with colonoscopies; you have advancing technology where we can potentially detect tumor cell DNA in the stool sample, which is leading to earlier diagnosis. And sometimes that effect will skew statistics and make it look like the incidence is really on the rise, but deeper analysis shows you that part of that is due to earlier detection and more screening,” he said. “So that could be one facet of the equation.”

Overall, pinpointing what could be driving this surge in colorectal cancer diagnoses among younger ages will not only help scientists better understand cancer as a disease, it will help doctors develop personalized risk assessments for their younger patients, Ohio State University’s Chakraborty said.

“Because most of the people who go on to develop colorectal cancer really have no family history – no known family history of colon cancer – so they would really not be aware of their risk until they begin to develop symptoms,” he said.

“Having a personalized risk assessment tool that will take into account their lifestyle, their environmental factors, genetic factors – I think if we have that, then it would allow us hopefully, in the future, to provide some personalized recommendations on when a person should be screened for colorectal cancer and what should be the modality of screening based on their risk,” he said. “Younger adults tend to develop colon cancer mostly in the left side, whereas, as we get older, colon cancer tends to develop more on the right side. So there’s a little difference in how we could screen younger adults versus older adults.”

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