Is the woolly mammoth really on the brink of being resurrected?

Unlike extinct woolly mammoths, most edited elephants with mammoth-like traits would have no tusks, to get around ivory poaching

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A company set up to resurrect extinct animals says it has achieved a major breakthrough in its goal of bringing back the woolly mammoth. On 6 March, Colossal announced that its team had managed to turn normal elephant cells into stem cells, which could lead to a mammoth-like creature. “This is a momentous step,” its CEO, Ben Lamm, said in a press release. Here’s what you need to know.

Is it really possible to bring the woolly mammoth back from extinction?

No it isn’t and never will be. While the genomes of several frozen mammoths have been sequenced, these are riddled with gaps. However, it should be possible to edit the genomes of living elephants to make them mammoth-like. Colossal acknowledges on its website that what it plans to create will be “a cold-resistant elephant”, but says the animal will have “all the core biological traits of the Woolly Mammoth”.

Will these edited elephants look like mammoths?

According to Colossal, they will even sound like them, though how it knows what mammoths sounded like is unclear. When it comes to their appearance, there will be at least one major difference: the vast majority will have no tusks to avoid ivory poaching, says George Church, Colossal co-founder. Those with tusks could be kept only in places with heavy surveillance, he says.

Colossal also plans to make the mammoth-like elephants resistant to a highly fatal disease caused by elephant endotheliotropic herpesviruses.

Why does Colossal need to make elephant stem cells?

The company has been editing the genomes of elephant cells to make them more mammoth-like. But to create a living mammoth-like elephant, it needs to generate embryos containing an edited genome. In theory, one way to do this is to turn gene-edited elephant cells into so-called induced pluripotent stem cells, and then to turn those into eggs and sperm cells.

What are induced pluripotent stem cells?

Pluripotent stem cells can turn into any cell in the body, including eggs and sperm. They occur naturally in embryos, but can also be made from adult cells by adding certain proteins, hence the “induced”. They have been made in many animal species, but, before now, no one had managed to induce elephant cells to become pluripotent.

Why is it hard to induce elephant cells to become pluripotent?

At least in part, it is probably because these large, long-lived animals need to have better anticancer mechanisms and that means tighter control on the growth of stem cells.

How did Colossal manage it?

Among other things, it genetically modified Asian elephant cells to permanently produce the key proteins. Even then, it still took two months to transform the cells into induced pluripotent stem cells. “We do want to make the process more efficient and faster, but I think it’s a great start,” says Eriona Hysolli at Colossal. The DNA that codes for the key proteins can be easily removed, she says.

So now Colossal will turn these induced pluripotent stem cells into eggs and sperm?

That’s the plan, but it could take many years. Turning induced pluripotent stem cells into eggs and sperm is far from easy. “It’s been done mainly in two species, which is mouse and human,” says Church. “And neither one of them is perfect.”

Does this mean it could be decades before mammoth-like elephants can be created?

Colossal claims its first “mammoth” will be born by 2028. Hysolli says the researchers aim to make just 50 to 100 genetic edits to elephant cells, which is feasible. But to generate embryos in time to meet the deadline, they will almost certainly have to transfer the edited genomes into elephant eggs using the cloning technique used to create Dolly the sheep. Because elephants have a two-year gestation period, these embryos would have to be created and implanted by around the end of 2026.

Will cloning the edited cells work?

It might, but, typically, just a few per cent of cloned embryos develop into healthy animals. “There are bound to be failed attempts. How many elephant cows will have to be subjected to the experimental pregnancies?” asks stem cell expert Dusko Ilic at King’s College London. “Just because we have the capability to do something new, that does not mean that we should pursue it without careful consideration of the ethical implications and consequences.”

Where will these mammoth-like elephants live? Given the war in Ukraine and Russia’s claims about US bioweapons, isn’t there close to zero chance of Russia allowing genetically reincarnated mammoths to be released in Siberia?

“Keep in mind that mammoths were everywhere in the Arctic circle and not just in Siberia,” says Hysolli. Alaska and Canada are also possibilities, she says, and Colossal is already having “very fruitful collaborations” with government agencies, local governments and Indigenous peoples.

Why is Colossal aiming to bring back the mammoth?

The company claims that rewilding the Arctic area with mammoths can help limit climate change by reducing permafrost melt and locking away carbon in the form of frozen organic material. “The Arctic is the perfect place to be sequestering carbon because every year it freezes another layer of topsoil,” says Church. “And then the herbivores poop on top of that.” 

Could mammoth-like creatures really help limit further warming in the Arctic?

That remains to be established, but there is some plausibility. One small study suggests large herbivores can lower permafrost temperatures by flattening insulating snow in winter. And if the edited elephants limited forest expansion, that would also help, as dark trees in previously flat, snowy areas can have a warming effect by absorbing more sunshine. But many thousands would be needed to have a significant impact.

Are you saying Colossal aims to have tens of thousands of these creatures roaming the Arctic?

Yes, that is the aim. Based on the growth of elephant populations in favourable conditions, New Scientist estimates it could take a century or more to breed this many mammoth-like elephants from a small starting population.

But Church says Colossal is developing artificial uteruses that will bypass the usual limits. “So we could, in principle, do this at whatever scale the world wants and needs. If they don’t need it, then we won’t scale it up,” he says.

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‘Every tenth of a degree matters’: UN climate report is a call for action, not despair

The latest report by the UN’s climate advisory panel has once again highlighted the need for urgent action against human-induced climate change, noting that the tools to prevent climate catastrophe already exist. While hopes of limiting global warming at 1.5C are rapidly fading, climate experts stress that “every additional tenth of a degree matters” to mitigate the already dire consequences of our planet warming. 

The 36-page “summary for policymakers”, a synthesis of nine years of research by the Intergovernmental Panel on Climate Change (IPCC), is a stark reminder that the devastating impacts of climate change are hitting faster than expected – and that failure to take decisive action could make some of those consequences irreversible. 

“Humanity is on thin ice – and that ice is melting fast,” UN Secretary-General Antonio Guterres warned on Monday as he presented the report’s key findings. “Our world needs climate action on all fronts – everything, everywhere, all at once.” 

The IPCC report says our planet is on course to reach 1.5 degrees Celsius above pre-industrial levels – considered a safer limit to global warming – in little over a decade. Its dire warning comes just eight years after the COP21 climate summit in Paris made the 1.5C threshold a beacon for climate policies. 

“Since the Paris Accord, the stated objective of states has been to keep global warming well below 2C above pre-industrial levels – and to step up efforts to limit it to 1.5C,” says Wolfgang Cramer, a research director at the Mediterranean Institute of Marine and Terrestrial Biodiversity and Ecology (IMBE).  

“This overall objective provided a horizon and a specific target for climate policies,” adds Cramer, who co-authored the IPCC’s last major report in 2022. “But when you look at the current trajectories and the poor efforts mustered by governments, it does indeed appear highly unlikely that we can meet that second target.” 

The figures speak for themselves. The IPCC says greenhouse gas emissions would need to be slashed by 45% by 2030 for there to be any chance of capping global warming at 1.5C. That would mean annual cuts equivalent to the one witnessed at the height of the Covid-19 pandemic in 2020, when the world’s economies ground to a halt. 

As things stand, humanity is well off the mark. According to the IPCC’s projections, our planet is on course for global heating of 2.5C by the end of the century if governments stick to their emissions pledges – and 2.8C if they stick to current policy. 

The planet’s ‘fever’ 

While the outlook is dire, it should not be cause for fatalism and inaction, experts caution.  

“Our actions right now will determine the extent of global warming in the long run. The objective is to ensure it remains as low as possible,” says Cramer, for whom the 1.5C target “is already too high” to avert major consequences for the planet. 

“We’re currently at 1.2C and already we are bearing the consequences, with an increase in heatwaves, droughts and flooding,” he explains. 


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To understand the significance of each fraction of a degree, Cramer draws a parallel with a human suffering from fever. Add one degree Celsius to the normal body temperature of 37C and the person will feel unwell and have headache. Add 2C and the suffering increases. At 3C it becomes dangerous, particularly if the person is vulnerable. 

The same goes for our planet, Cramer adds.  

“The consequences will differ at each degree and in different parts of the world: they will be most severe in places that are most vulnerable,” he says. “1.5C will always be better than 1.6C, which will always be preferable to 1.7C. Every tenth of a degree matters.” 

Biodiversity under threat 

The consequences of this global “fever” are increasingly evident, starting with the extinction of biodiversity.  

In 2015, the year of the Paris Accord, the Bramble Cay Melomy, a small rodent that lived on a speck of land off the coast of Papua New Guinea, became the first known mammal to go extinct as a result of human-caused climate change. 

“Scientists have shown that its disappearance was caused by rising sea levels submerging its habitat,” Camille Parmesan, a climate and biodiversity expert at the CNRS research centre, told FRANCE 24 in an interview in December. 

“We have also documented the disappearance of 92 species of amphibians, killed because of the proliferation of a fungus that developed as a result of climate change modifying ecosystems,” Parmesan added.  

>> ‘Humanity is bullying nature – and we will pay the price,’ WWF chief tells FRANCE 24

Corals are another obvious casualty. At 1.5°C, 70% to 90% of reefs could disappear. At 2°C, the figure rises to 99%. 

Experts at the UN-backed biodiversity agency IPBES say more than a million species are currently threatened with extinction, with climate change becoming the “most significant” menace. “The more it increases, the more ecosystems are disrupted, with consequences for wildlife,” an agency report stated in 2021. 

Extreme weather 

“Each additional degree will translate into increasingly frequent and severe weather events, with ever greater consequences for the 3.3 billion people who live in vulnerable areas,” adds Cramer. 

For several years now, scientists have been investigating links between climate change and extreme weather events, a field known as “attribution science”. Their findings confirm that heatwaves, floods and hurricanes are increasing in intensity, magnitude and frequency as a result of global warming. Research has thus established that climate change made the devastating heatwave that hit India and Pakistan in March and April last year thirty times more likely. 

In this context, “decision makers should also focus their efforts on slowing down global warming” – in addition to curbing it, says glaciologist Gerhard Krinner, one of the authors of the latest IPCC report.  

“The faster climate change takes place the less time people will have to adapt,” he explains. “This in turn will increase the risk of severe shortages, famines and conflicts.” 

Tipping points 

Both experts flag the danger of reaching “tipping points” that would be extremely difficult to reverse, such as a destabilisation of the Antarctic ice cap.  

While the likelihood of catastrophic ice-sheet melting is currently still low, “it increases as the planet warms and there is a real risk of the rise in sea levels accelerating dramatically at between 1.5C and 2C”, Cramer warns.   

Should the Antarctic’s permafrost come to melt, it would release vast amounts of greenhouse gases trapped under the ice, in turn further warming the planet and accelerating ice melt. Other examples of tipping points include the Amazon rainforest turning to savannah and Greenland’s ice cap melting. 

Each of these scenarios can be avoided, the experts insist, provided there is a political will to do so. 

“We now have multiple solutions that are readily available to slow down and limit climate change,” says Cramer, for whom “the obstacle is no longer innovation – but politics”.  

“Today’s efforts will make all the difference in the long term,” adds Krinner. “We can still spare ourselves those extra tenths of a degree.” 

This article was translated from the original in French.

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