No antibiotics worked, so this woman turned to a natural enemy of bacteria to save her husband’s life | CNN



CNN
 — 

In February 2016, infectious disease epidemiologist Steffanie Strathdee was holding her dying husband’s hand, watching him lose an exhausting fight against a deadly superbug infection.

After months of ups and downs, doctors had just told her that her husband, Tom Patterson, was too racked with bacteria to live.

“I told him, ‘Honey, we’re running out of time. I need to know if you want to live. I don’t even know if you can hear me, but if you can hear me and you want to live, please squeeze my hand.’

“All of a sudden, he squeezed really hard. And I thought, ‘Oh, great!’ And then I’m thinking, ‘Oh, crap! What am I going to do?’”

What she accomplished next could easily be called miraculous. First, Strathdee found an obscure treatment that offered a glimmer of hope — fighting superbugs with phages, viruses created by nature to eat bacteria.

Then she convinced phage scientists around the country to hunt and peck through molecular haystacks of sewage, bogs, ponds, the bilge of boats and other prime breeding grounds for bacteria and their viral opponents. The impossible goal: quickly find the few, exquisitely unique phages capable of fighting a specific strain of antibiotic-resistant bacteria literally eating her husband alive.

Next, the US Food and Drug Administration had to greenlight this unproven cocktail of hope, and scientists had to purify the mixture so that it wouldn’t be deadly.

Yet just three weeks later, Strathdee watched doctors intravenously inject the mixture into her husband’s body — and save his life.

Their story is one of unrelenting perseverance and unbelievable good fortune. It’s a glowing tribute to the immense kindness of strangers. And it’s a story that just might save countless lives from the growing threat of antibiotic-resistant superbugs — maybe even your own.

“It’s estimated that by 2050, 10 million people per year — that’s one person every three seconds — is going to be dying from a superbug infection,” Strathdee told an audience at Life Itself, a 2022 health and wellness event presented in partnership with CNN.

“I’m here to tell you that the enemy of my enemy can be my friend. Viruses can be medicine.”

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How this ‘perfect predator’ saved his life after nine months in the hospital

During a Thanksgiving cruise on the Nile in 2015, Patterson was suddenly felled by severe stomach cramps. When a clinic in Egypt failed to help his worsening symptoms, Patterson was flown to Germany, where doctors discovered a grapefruit-size abdominal abscess filled with Acinetobacter baumannii, a virulent bacterium resistant to nearly all antibiotics.

Found in the sands of the Middle East, the bacteria were blown into the wounds of American troops hit by roadside bombs during the Iraq War, earning the pathogen the nickname “Iraqibacter.”

“Veterans would get shrapnel in their legs and bodies from IED explosions and were medevaced home to convalesce,” Strathdee told CNN, referring to improvised explosive devices. “Unfortunately, they brought their superbug with them. Sadly, many of them survived the bomb blasts but died from this deadly bacterium.”

Today, Acinetobacter baumannii tops the World Health Organization’s list of dangerous pathogens for which new antibiotics are critically needed.

“It’s something of a bacterial kleptomaniac. It’s really good at stealing antimicrobial resistance genes from other bacteria,” Strathdee said. “I started to realize that my husband was a lot sicker than I thought and that modern medicine had run out of antibiotics to treat him.”

With the bacteria growing unchecked inside him, Patterson was soon medevaced to the couple’s hometown of San Diego, where he was a professor of psychiatry and Strathdee was the associate dean of global health sciences at the University of California, San Diego.

“Tom was on a roller coaster — he’d get better for a few days, and then there would be a deterioration, and he would be very ill,” said Dr. Robert “Chip” Schooley, a leading infectious disease specialist at UC San Diego who was a longtime friend and colleague. As weeks turned into months, “Tom began developing multi-organ failure. He was sick enough that we could lose him any day.”

Patterson's body was systemically infected with a virulent drug-resistant bacteria that also infected troops in the Iraq War, earning the pathogen the nickname

After that reassuring hand squeeze from her husband, Strathdee sprang into action. Scouring the internet, she had already stumbled across a study by a Tbilisi, Georgia, researcher on the use of phages for treatment of drug-resistant bacteria.

A phone call later, Strathdee discovered phage treatment was well established in former Soviet bloc countries but had been discounted long ago as “fringe science” in the West.

“Phages are everywhere. There’s 10 million trillion trillion — that’s 10 to the power of 31 — phages that are thought to be on the planet,” Strathdee said. “They’re in soil, they’re in water, in our oceans and in our bodies, where they are the gatekeepers that keep our bacterial numbers in check. But you have to find the right phage to kill the bacterium that is causing the trouble.”

Buoyed by her newfound knowledge, Strathdee began reaching out to scientists who worked with phages: “I wrote cold emails to total strangers, begging them for help,” she said at Life Itself.

One stranger who quickly answered was Texas A&M University biochemist Ryland Young. He’d been working with phages for over 45 years.

“You know the word persuasive? There’s nobody as persuasive as Steffanie,” said Young, a professor of biochemistry and biophysics who runs the lab at the university’s Center for Phage Technology. “We just dropped everything. No exaggeration, people were literally working 24/7, screening 100 different environmental samples to find just a couple of new phages.”

While the Texas lab burned the midnight oil, Schooley tried to obtain FDA approval for the injection of the phage cocktail into Patterson. Because phage therapy has not undergone clinical trials in the United States, each case of “compassionate use” required a good deal of documentation. It’s a process that can consume precious time.

But the woman who answered the phone at the FDA said, “‘No problem. This is what you need, and we can arrange that,’” Schooley recalled. “And then she tells me she has friends in the Navy that might be able to find some phages for us as well.”

In fact, the US Naval Medical Research Center had banks of phages gathered from seaports around the world. Scientists there began to hunt for a match, “and it wasn’t long before they found a few phages that appeared to be active against the bacterium,” Strathdee said.

Dr. Robert

Back in Texas, Young and his team had also gotten lucky. They found four promising phages that ravaged Patterson’s antibiotic-resistant bacteria in a test tube. Now the hard part began — figuring out how to separate the victorious phages from the soup of bacterial toxins left behind.

“You put one virus particle into a culture, you go home for lunch, and if you’re lucky, you come back to a big shaking, liquid mess of dead bacteria parts among billions and billions of the virus,” Young said. “You want to inject those virus particles into the human bloodstream, but you’re starting with bacterial goo that’s just horrible. You would not want that injected into your body.”

Purifying phage to be given intravenously was a process that no one had yet perfected in the US, Schooley said, “but both the Navy and Texas A&M got busy, and using different approaches figured out how to clean the phages to the point they could be given safely.”

More hurdles: Legal staff at Texas A&M expressed concern about future lawsuits. “I remember the lawyer saying to me, ‘Let me see if I get this straight. You want to send unapproved viruses from this lab to be injected into a person who will probably die.’ And I said, “Yeah, that’s about it,’” Young said.

“But Stephanie literally had speed dial numbers for the chancellor and all the people involved in human experimentation at UC San Diego. After she calls them, they basically called their counterparts at A&M, and suddenly they all began to work together,” Young added.

“It was like the parting of the Red Sea — all the paperwork and hesitation disappeared.”

The purified cocktail from Young’s lab was the first to arrive in San Diego. Strathdee watched as doctors injected the Texas phages into the pus-filled abscesses in Patterson’s abdomen before settling down for the agonizing wait.

“We started with the abscesses because we didn’t know what would happen, and we didn’t want to kill him,” Schooley said. “We didn’t see any negative side effects; in fact, Tom seemed to be stabilizing a bit, so we continued the therapy every two hours.”

Two days later, the Navy cocktail arrived. Those phages were injected into Patterson’s bloodstream to tackle the bacteria that had spread to the rest of his body.

“We believe Tom was the first person to receive intravenous phage therapy to treat a systemic superbug infection in the US,” Strathdee told CNN.

“And three days later, Tom lifted his head off the pillow out of a deep coma and kissed his daughter’s hand. It was just miraculous.”

Patterson awoke from a coma after receiving an intravenous dose of phages tailored to his bacteria.

Today, nearly eight years later, Patterson is happily retired, walking 3 miles a day and gardening. But the long illness took its toll: He was diagnosed with diabetes and is now insulin dependent, with mild heart damage and gastrointestinal issues that affect his diet.

“He isn’t back surfing again, because he can’t feel the bottoms of his feet, and he did get Covid-19 in April that landed him in the hospital because the bottoms of his lungs are essentially dead,” Strathdee said.

“As soon as the infection hit his lungs he couldn’t breathe and I had to rush him to the hospital, so that was scary,” she said. “He remains high risk for Covid but we’re not letting that hold us hostage at home. He says, ‘I want to go back to having as normal life as fast as possible.’”

To prove it, the couple are again traveling the world — they recently returned from a 12-day trip to Argentina.

“We traveled with a friend who is an infectious disease doctor, which gave me peace of mind to know that if anything went sideways, we’d have an expert at hand,” Strathdee said.

“I guess I’m a bit of a helicopter wife in that sense. Still, we’ve traveled to Costa Rica a couple of times, we’ve been to Africa, and we’re planning to go to Chile in January.”

Patterson’s case was published in the journal Antimicrobial Agents and Chemotherapy in 2017, jump-starting new scientific interest in phage therapy.

“There’s been an explosion of clinical trials that are going on now in phage (science) around the world and there’s phage programs in Canada, the UK, Australia, Belgium, Sweden, Switzerland, India and China has a new one, so it’s really catching on,” Strathdee told CNN.

Some of the work is focused on the interplay between phages and antibiotics — as bacteria battle phages they often shed their outer shell to keep the enemy from docking and gaining access for the kill. When that happens, the bacteria may be suddenly vulnerable to antibiotics again.

“We don’t think phages are ever going to entirely replace antibiotics, but they will be a good adjunct to antibiotics. And in fact, they can even make antibiotics work better,” Strathdee said.

In San Diego, Strathdee and Schooley opened the Center for Innovative Phage Applications and Therapeutics, or IPATH, in 2018, where they treat or counsel patients suffering from multidrug-resistant infections. The center’s success rate is high, with 82% of patients undergoing phage therapy experiencing a clinically successful outcome, according to its website.

Schooley is running a clinical trial using phages to treat patients with cystic fibrosis who constantly battle Pseudomonas aeruginosa, a drug-resistant bacteria that was also responsible for the recent illness and deaths connected to contaminated eye drops manufactured in India.

And a memoir the couple published in 2019 — “The Perfect Predator: A Scientist’s Race to Save Her Husband From a Deadly Superbug” — is also spreading the word about these “perfect predators” to what may soon be the next generation of phage hunters.

VS Phages Sanjay Steffanie

How naturally occurring viruses could help treat superbug infections

“I am getting increasingly contacted by students, some as young as 12,” Strathdee said. “There’s a girl in San Francisco who begged her mother to read this book and now she’s doing a science project on phage-antibiotic synergy, and she’s in eighth grade. That thrills me.”

Strathdee is quick to acknowledge the many people who helped save her husband’s life. But those who were along for the ride told CNN that she and Patterson made the difference.

“I think it was a historical accident that could have only happened to Steffanie and Tom,” Young said. “They were at UC San Diego, which is one of the premier universities in the country. They worked with a brilliant infectious disease doctor who said, ‘Yes,’ to phage therapy when most physicians would’ve said, ‘Hell, no, I won’t do that.’

“And then there is Steffanie’s passion and energy — it’s hard to explain until she’s focused it on you. It was like a spiderweb; she was in the middle and pulled on strings,” Young added. “It was just meant to be because of her, I think.”

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Death toll from Sudan fighting tops 180 as clashes in Khartoum enter third day

As explosions and gunfire thundered outside, Sudanese in the capital Khartoum and other cities huddled in their homes for a third day Monday, while the army and a powerful rival force battled in the streets for control of the country.  

At least 185 people have been killed and over 1,800 wounded since the fighting erupted, UN envoy Volker Perthes told reporters. The two sides are using tanks, artillery and other heavy weapons in densely populated areas. Fighter jets swooped overhead and anti-aircraft fire lit up the skies as darkness fell.

The toll could be much higher because there are many bodies in the streets around central Khartoum that no one can reach because of the clashes. There has been no official word on how many civilians or combatants have been killed. The doctors’ syndicate earlier put the number of civilian deaths at 97.

The sudden outbreak of violence over the weekend between the nation’s two top generals, each backed by tens of thousands of heavily armed fighters, trapped millions of people in their homes or wherever they could find shelter, with supplies running low in many areas. 

Top diplomats on four continents scrambled to broker a truce, and the UN Security Council was set to discuss the crisis.

“Gunfire and shelling are everywhere,” Awadeya Mahmoud Koko, head of a union for thousands of tea vendors and other food workers, said from her home in a southern district of Khartoum.

She said a shell stuck a neighbour’s house Sunday, killing at least three people. “We couldn’t take them to a hospital or bury them.”

In central Khartoum, sustained gunfire erupted and white smoke rose near the main military headquarters, a major battle front.

Nearby, at least 88 students and staffers have been trapped in the engineering college library at Khartoum University since the start of fighting, one of the students said in a video posted online Monday.

One student was killed during clashes outside and another wounded, he said. They do not have food or water, he said, showing a room full of people sleeping on the floor. 

Even in a country with a long history of military coups, the scenes of fighting in the capital and its adjoining city Omdurman across the Nile River were unprecedented. The turmoil comes just days before Sudanese were to celebrate Eid al-Fitr, the holiday marking the end of Ramadan, the Islamic month of fasting.

The power struggle pits Gen. Abdel-Fattah Burhan, the commander of the armed forces, against Gen. Mohammed Hamdan Dagalo, the head of the Rapid Support Forces, a paramilitary group. The former allies jointly orchestrated an October 2021 military coup. The violence has raised the specter of civil war just as Sudanese were trying to revive the drive for a democratic, civilian government after decades of military rule.

Under international pressure, Burhan and Dagalo had recently agreed to a framework agreement with political parties and pro-democracy groups, but the signing was repeatedly delayed as tensions rose over the integration of the RSF into the armed forces and the future chain of command.

The US, the UN and others have called for a truce. Egypt, which backs Sudan’s military, and Saudi Arabia and the United Arab Emirates — which forged close ties to the RSF in recent years as it sent thousands of fighters to support their war in Yemen — have also called for both sides to stand down. 

But both generals have thus far dug in, demanding the other’s surrender and ruling out negotiations. 

Dagalo, whose forces grew out of the notorious Janjaweed militias in Sudan’s Darfur region, has portrayed himself as a defender of democracy and branded Burhan as the aggressor and a “radical Islamist.” Both generals have a long history of human rights abuses and their forces have cracked down on pro-democracy activists.

Heavy gunbattles raged in multiple parts of the capital and Omdurman, where the two sides have brought in tens of thousands of troops, positioning them in nearly every neighbourhood. At least six hospitals in Khartoum were shut down because of damage from fighting, nearby clashes or because they ran low on fuel, said Atiya Abdalla Atiya, secretary of the Sudan Doctors’ Syndicate.

Hadia Saeed said she and her three children were sheltering in one room on the ground floor of their home for fear of the shelling as gunfire rattled across their Bahri district in north Khartoum. They have food for a few more days, but “after that we don’t know what to do,” she said. 

Residents said fierce fighting with artillery and other heavy weapons raged Monday afternoon in the Gabra neighbourhood southwest of Khartoum. People were trapped and screaming inside their homes, said Asmaa al-Toum, a physician living in the area.

Fighting has been particularly fierce around each side’s main bases and at strategic government buildings — all of which are in residential areas.

The military on Monday claimed to have secured the main television building in Omdurman, fending off the RSF after days of fighting. State-run Sudan TV resumed broadcasting. 

On Sunday, the RSF said it abandoned its main barracks and base, in Omdurman, which the armed forces had pounded with airstrikes. Online videos Monday purported to show the bodies of dozens of men said to be RSF fighters at the base, strewn over beds, the floor of a clinic and outside in a yard. The authenticity of the videos could not be confirmed independently.

The military and RSF were also fighting in most major centers around the country, including in the western Darfur region and parts of the north and the east, by the borders with Egypt and Ethiopia. Battles raged Monday around a strategic airbase in Merowe, some 350 kilometers (215 miles) northwest of the capital, with both sides claiming control of the facility.

Only four years ago, Sudan inspired hope after a popular uprising helped depose long-time autocratic leader Omar al-Bashir

But the turmoil since, especially the 2021 coup, has frustrated the democracy drive and wrecked the economy. A third of the population — around 16 million people — now depends on humanitarian assistance in the resource-rich nation, Africa’s third largest.

Save the Children, an international charity, said it has temporarily suspended most of its operations across Sudan. It said looters raided its offices in Darfur, stealing medical supplies, laptops, vehicles and a refrigerator.

The World Food Program suspended operations over the weekend after three employees were killed in Darfur, and the International Rescue Committee has also halted most operations.

With the US, European Union, African and Arab nations all calling for an end to fighting, the UN Security Council was to discuss the developments in Sudan later Monday. UN Secretary-General Antonio Guterres said he was consulting with the Arab League, African Union and leaders in the region, urging anyone with influence to press for peace. 

Egyptian Foreign Minister Sameh Shoukry discussed the violence in separate phone calls with his Saudi and French counterparts, the Egyptian Foreign Ministry said.

At a meeting of the Group of Seven wealthy nations in Japan on Monday, US Secretary of State Antony Blinken said the Sudanese “want the military back in the barracks. They want democracy. They want the civilian-led government, Sudan needs to return to that path.”

(AP)

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Violent power struggle continues in Sudan as army bombs paramilitary bases

Sudan’s army appeared to gain the upper hand on Sunday in a bloody power struggle with rival paramilitary forces, pounding their bases with air strikes, witnesses said, and at least 59 civilians were killed including three UN workers.

The fighting erupted on Saturday between army units loyal to General Abdel Fattah al-Burhan, head of Sudan‘s transitional governing Sovereign Council, and the paramilitary Rapid Support Forces (RSF), led by General Mohamed Hamdan Dagalo, known as Hemedti, who is deputy head of the council.

It was the first such outbreak since both joined forces to oust veteran Islamist autocrat Omar Hassan al-Bashir in 2019 and was sparked by a disagreement over the integration of the RSF into the military as part of a transition towards civilian rule.

Burhan and Hemedti agreed a three-hour pause in fighting from 4 pm local time (1400 GMT to 1700 GMT) to allow humanitarian evacuations proposed by the United Nations, the UN mission in Sudan said, but the deal was widely ignored after a brief period of relative calm.

As night fell residents reported the boom of artillery and roar of warplanes in the Kafouri district of Bahri, which has an RSF base, across the Nile river from the capital Khartoum.

Eyewitnesses told Reuters the army was renewing air strikes on RSF bases in Omdurman, Khartoum’s sister city across the Nile, and the Kafouri and Sharg El-Nil districts of adjacent Bahri, putting RSF fighters to flight.

The United States, China, Russia, Egypt, Saudi Arabia, the U.N. Security Council, European Union and African Union have appealed for a quick end to the hostilities that threaten to worsen instability in an already volatile wider region.

Efforts by neighbours and regional bodies to end the violence intensified on Sunday. Egypt offered to mediate, and regional African bloc Intergovernmental Authority on Development plans to send the presidents of Kenya, South Sudan and Djibouti as soon as possible to reconcile Sudanese groups in conflict, Kenyan President William Ruto’s office said on Twitter.

The eruption of fighting over the weekend followed rising tensions over the RSF’s integration into the military. Discord over the timetable for that has delayed the signing of an internationally-backed agreement with political parties on a transition to democracy after a 2021 military coup.

Clashes in Khartoum 

A statement by the army said there were ongoing clashes in the vicinity of military headquarters in central Khartoum, and said that RSF soldiers were stationing snipers on buildings, but that they were “monitored and being dealt with.”

Earlier on Sunday, witnesses and residents told Reuters that the army had carried out air strikes on RSF barracks and bases in the Khartoum region and managed to destroy most of the paramilitaries’ facilities.

They said the army had also wrested back control over much of Khartoum’s presidential palace from the RSF after both sides claimed to control it and other key installations in Khartoum, where heavy artillery and gun battles raged into Sunday.

RSF members remained inside Khartoum international airport besieged by the army but it was holding back from striking them to avoid wreaking major damage, witnesses said.

But a major problem, witnesses and residents said, was posed by thousands of heavily armed RSF members deployed inside neighbourhoods of Khartoum and other cities, with no authority able to control them.

“We’re scared, we haven’t slept for 24 hours because of the noise and the house shaking. We’re worried about running out of water and food, and medicine for my diabetic father,” Huda, a young resident in southern Khartoum told Reuters.

“There’s so much false information and everyone is lying. We don’t know when this will end, how it will end,” she added.

A protracted confrontation could plunge Sudan into widespread conflict as it struggles with economic breakdown and tribal violence, derailing efforts to move towards elections.

Energy-rich powers Saudi Arabia and the United Arab Emirates have sought to shape events in Sudan, seeing the transition away from toppled strongman Bashir’s rule as a way to roll back Islamist influence and improve stability in the region.

They have also pursued investments in sectors including agriculture, where Sudan holds vast potential, and ports on Sudan’s Red Sea coast.

Civilian casualties

The Central Committee of Sudanese Doctors reported at least 56 civilians had been killed and 595 people including combatants had been wounded since the fighting erupted.

Scores of military personnel were killed, the doctors’ committee said, without giving a specific number due to a lack of first-hand information from hospitals.

The UN World Food Programme said it had temporarily halted all operations in hunger-stricken areas of Sudan after three Sudanese employees were killed during fighting in North Darfur and a WFP plane was hit during a gun battle at Khartoum airport.

United Nations Secretary-General Antonio Guterres condemned the killings and called for accountability.

“Those responsible should be brought to justice without delay,” Guterres said on Twitter. “Humanitarian workers are #NotATarget.”

Volker Perthes, UN special envoy for Sudan and head of its country mission, said in a statement he was appalled by reports of shelling and looting impacting UN and other humanitarian facilities.

Saudi Foreign Minister Faisal bin Farhan bin Al-Saud had separate phone calls with Burhan and Hemedti and called for an end to military escalation, Saudi state media said on Sunday. The minister affirmed Riyadh’s call for calm.

In a speech to an Arab League meeting on the crisis on Sunday, Sudan said the Sudanese should be allowed to reach a settlement internally without foreign interference.

The armed forces said it would not negotiate with the RSF unless the force dissolved. The army told soldiers seconded to the RSF to report to nearby army units, which could deplete RSF ranks if they obey.

RSF leader Hemedti, deputy head of state, called military chief Burhan a “criminal” and a “liar”.

State television cut its transmission on Sunday afternoon, a move employees said was meant to prevent propaganda broadcasts by the RSF after its forces entered the main state broadcaster building in Omdurman and started to air pro-RSF programming.

(REUTERS)

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Air strikes hit Sudan capital as clashes escalate between army and paramilitaries

Issued on: Modified:

Three civilians died in battles between Sudanese paramilitaries and the regular army, which said it launched air strikes against them, sparking global concern days after the army warned the country was at a “dangerous” turning point. 

The paramilitaries said they were in control of the presidential place as well as Khartoum airport, claims denied by the army, as civilian leaders called for an immediate ceasefire to prevent the country’s “total collapse”.

The doctors’ union reported the three civilian deaths, including at Khartoum airport which is in the city centre, and in North Kordofan state. At least nine others were wounded, the medics said.

The eruption of violence came after weeks of deepening tensions between military leader Abdel Fattah al-Burhan and his number two, paramilitary commander Mohamed Hamdan Daglo, over the planned integration of the paramilitary Rapid Support Forces (RSF) into the regular army.

That was a key element of talks to finalise a deal that would return the country to civilian rule and end the crisis sparked by their 2021 coup, which triggered a deepening economic crisis in what was already one of the world’s poorest countries.

US Secretary of State Antony Blinken said he was “deeply concerned” and urged both sides to “stop the violence immediately”, a call echoed by the United Nations, African Union, Arab League, regional bloc IGAD and the European Union.


Russia‘s foreign ministry said there was “serious concern in Moscow,” which called for urgent steps toward a ceasefire.

The army said it had carried out air strikes and “destroyed” two RSF bases in Khartoum. 

More than 120 civilians had already been killed in a crackdown on regular pro-democracy demonstrations since the coup.

‘Sweeping attack’ 

The RSF said its forces had taken control of Khartoum airport, after witnesses reported seeing truckloads of fighters entering the airport compound, as well as the presidential palace — where Burhan is officially based — and other key sites.

Its claims were quickly denied by the army, who said the airport and other bases remain under their “full control”, publishing a photograph of black smoke billowing from what it said was the RSF headquarters.

The army also accused the paramilitaries of burning civilian airliners at the airport, and Saudi flag carrier Saudia said it had suspended all flights to and from Sudan until further notice after one of its Airbus A330 planes “was involved in an accident”.

RSF chief Daglo vowed no let-up. “We will not stop fighting until we capture all the army bases and the honourable members of the armed forces join us,” he told Al Jazeera. 

Created in 2013, the RSF emerged from the Janjaweed militia that then president Omar al-Bashir unleashed against non-Arab ethnic minorities in the western Darfur region a decade earlier, drawing accusations of war crimes. 

A plan to integrate the RSF into the regular army is one of the main points of contention, analysts have said.


Haggling between the two men has twice forced postponement of the signing of an agreement with civilian factions setting out a roadmap for restoring the democratic transition disrupted by the 2021 coup.

Witnesses also reported clashes around the state media building in Khartoum’s sister city Omdurman.

Outside the capital, witness Eissa Adam said explosions and gunfire had been heard across the North Darfur state capital of El Fasher, where civilians were hunkered down inside their homes.

Witnesses in the South Darfur state capital Nyala also reported clashes.

The two sides traded blame for starting the fighting.

The RSF said they were “surprised Saturday with a large force from the army entering camps”, reporting a “sweeping attack with all kinds of heavy and light weapons”.

Army spokesman Brigadier General Nabil Abdallah said the paramilitaries launched the fighting, attacking “several army camps in Khartoum and elsewhere around Sudan”.

“Clashes are ongoing and the army is carrying out its duty to safeguard the country”, he added.

Burhan, in a statement to Al Jazeera, said he “was surprised by Rapid Support Forces attacking his home at 9:00 am”, without giving details.

‘Slipping into abyss’ 

The military’s civilian interlocutors called on both sides “to immediately cease hostilities and spare the country slipping into the abyss of total collapse.” 

Their plea was echoed by US ambassador John Godfrey, who tweeted that he “woke up to the deeply disturbing sounds of gunfire and fighting” and was “currently sheltering in place with the embassy team, as Sudanese throughout Khartoum and elsewhere are doing”.


The head of the United Nations mission in Sudan, Volker Perthes, called for an “immediate” ceasefire, to “spare the country from further violence”. 

Western governments had been warning of the dangers of all-out fighting between the rival security forces since the army issued its warning to the paramilitaries on Thursday.

Daglo has said the 2021 coup was a “mistake” that failed to bring about change in Sudan and reinvigorated remnants of Bashir’s regime ousted by the army in 2019 following month of mass protests. 

Burhan, a career soldier from northern Sudan who rose the ranks under Bashir’s three-decade rule, maintained that the coup was “necessary” to bring more groups into the political process.

(AFP)



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Why Cristiano Ronaldo’s move to Saudi Arabia means so much for the Gulf monarchy’s sporting ambitions | CNN

Editor’s Note: A version of this story appears in today’s Meanwhile in the Middle East newsletter, CNN’s three-times-a-week look inside the region’s biggest stories. Sign up here.


Abu Dhabi, UAE
CNN
 — 

It’s a partnership that’s been hailed as “history in the making.”

One of the world’s most famous soccer stars landed in the Saudi capital Riyadh on Tuesday, where Cristiano Ronaldo was received in an extravagant ceremony, with excited children sporting his new club’s yellow and blue jerseys.

Oil-rich Saudi Arabia’s success in luring the five-time Ballon d’Or winner on a two-year contract with the kingdom’s Al Nassr FC is the Gulf monarchy’s latest step in realizing its sporting ambitions – seemingly at any cost.

According to Saudi state-owned media, Ronaldo will earn an estimated $200 million a year with Al Nassr, making him the world’s highest-paid soccer player.

Shortly after the 37-year-old’s signing with Al Nassr, the club’s Instagram page gained over 5.3 million new followers. Its official website was inaccessible after exceeding its bandwidth limit due to the sudden surge in traffic, and the hashtag #HalaRonaldo – Hello, Ronaldo in Arabic – was trending for days across the Middle East on Twitter.

Analysts say that his recruitment in Saudi Arabia is part of a wider effort by the kingdom to diversify its sources of revenue and become a serious player in the international sporting scene.

It is also seen as a move by the kingdom to shore up its image after it was tarnished by the 2018 dismemberment and killing of Washington Post columnist Jamal Khashoggi at the hands of Saudi agents, and a devastating war it started in Yemen in 2015.

Critics have decried the kingdom for “sportswashing,” an attempt to burnish one’s reputation through sport.

“I think Saudi Arabia has recognized a couple of years ago that to be a powerful nation internationally, you cannot just rely on hard power,” Danyel Reiche, a visiting research fellow and associate professor at Georgetown University Qatar, told CNN.

“You also need to invest in soft power, and the case of Qatar shows that this can work pretty well,” he said, adding that Saudi Arabia is following in the Qatari approach with sport, but with a delay of around 25 years.

Neighboring Qatar has also faced immense criticism since it won the bid to hosting last year’s FIFA World Cup in 2010.

Despite the smaller Gulf state facing similar accusations of “sportswashing,” the tournament has largely been viewed as a success, not least in exposing the world to a different view of the Middle East, thanks in part to Morocco’s success in reaching the semifinals and Saudi Arabia beating eventual World Cup champion Argentina in their opening group game.

Gulf nations engage in fierce competition to become the region’s premier entertainment and sporting hubs. The UAE, Saudi Arabia, Qatar and Bahrain, in close proximity to each other, each have their own Formula One racing event. But their competition hasn’t been confined to the region. Qatar, Saudi Arabia and the UAE have also bought trophy European soccer teams.

Riyadh is playing catchup with neighbors who have long realized the importance of investing in sports, said Simon Chadwick, professor of sport and geopolitical economy at SKEMA Business School in Lille, France, especially as its main source of income – oil – is being gradually shunned.

“This is part of an ongoing attempt to create more resilient economies that are more broadly based upon industries other than those that are derived from oil and gas,” Chadwick told CNN.

Ronaldo’s new club Al Nassr is backed by Qiddiya Investment Company (QIC), a subsidiary of the kingdom’s wealth fund, the Public Investment Fund (PIF), which has played a pivotal role in Saudi Arabia’s diversification plans.

“It is also a sign of interconnectedness, of globalization and of opening up to the rest of the world,” said Georgetown University’s Reiche.

The move is part of “several recent high profile moves in the sports world, including hosting the Andy Ruiz Jr. and Anthony Joshua world heavywight boxing championship bout in 2019, and launching the LIV Golf championship,” said Omar Al-Ubaydli, director of research at the Bahrain-based Derasat think tank. “It is a significant piece of a large puzzle that represents their economic restructuring.”

The kingdom has been on a path to not only diversify its economy, but also shift its image amid a barrage of criticism over its human rights record and treatment of women. Saudi Arabia is today hosting everything from desert raves to teaming up with renowned soccer players. Argentina’s Lionel Messi last year signed a lucrative promotional deal with the kingdom.

Hailed as the world’s greatest player, 35-year-old Messi ended this year’s World Cup tournament in Qatar with his team’s win over France, making his ambassadorship of even greater value to the kingdom.

The acquisition of such key global figures will also help combat the monarchy’s decades-long reputation of being “secretive” and “ultra-conservative,” James Dorsey, a senior fellow at the S. Rajaratnam School of International Studies in Singapore and an expert on soccer in the Middle East, told CNN’s Eleni Giokos on Wednesday.

Al-Ubaydli said that the kingdom wants to use high profile international sports “as a vehicle for advertising to the world its openness.”

Saudi Arabia bought the English Premier league club Newcastle United in 2021 through a three-party consortium, with PIF being the largest stakeholder. The move proved controversial, as Amnesty International and other human rights defenders worried it would overshadow the kingdom’s human rights violations.

Ronaldo’s work with Saudi Arabia is already being criticized by rights groups who are urging the soccer player to “draw attention to human rights issues” in Saudi Arabia.

“Saudi Arabia has an image problem,” especially since Khashoggi’s killing, says Reiche. But the kingdom’s recent investments in sports and entertainment are “not about sportswashing but about developing the country, social change and opening up to the world.”

Saudi Arabia is reportedly weighing a 2030 World Cup bid with Egypt and Greece, but the kingdom’s tourism ministry noted in November that it has not yet submitted an official bid. Chadwick believes that Ronaldo’s deal with Al Nassr, however, may help boost the kingdom’s bid should it choose it pursue it.

Another way Saudi Arabia may benefit from Ronaldo’s acquisition is that it will be able to improve commercial performance, says Chadwick, especially if this collaboration attracts further international talent.

“It is important to see Ronaldo not just as a geopolitical instrument,” said Chadwick, “There is still a commercial component to him and to the purpose he is expected to serve in Saudi Arabia.”

What Ronaldo’s move to Saudi Arabia shows is that the kingdom aspires “to be seen as being the best” and that it wants to be perceived as a “contender and a legitimate member of the international football community,” said Chadwick.

UAE FM meets Syria’s Assad in Damascus in further sign of thawing ties

Syrian President Bashar al-Assad received the United Arab Emirates Foreign Minister Sheikh Abdullah bin Zayed in Damascus on Wednesday in the latest sign of thawing relations between Assad and the Gulf state. The meeting addressed developments in Syria and the wider Middle East, according to UAE state news agency WAM.

  • Background: It was Abdullah bin Zayed’s first visit since a November 2021 meeting with Assad that led to the resumption of relations. Months later, in March 2022, Assad visited the UAE, his first visit to an Arab state since the start of Syria’s civil war.
  • Why it matters: A number of Assad’s former foes have been trying to mend fences with his regime. Last week, talks between the Syrian and Turkish defense ministers were held in Moscow in the highest-level encounter reported between the estranged sides since the war in Syria began. The regional rapprochement is yet to improve the lives of average Syrians. Syria is still under Western sanctions.

Turkish President Erdogan says he could meet with Assad

Turkish President Recep Tayyip Erdogan said in a speech on Thursday that he could meet the Syrian leader “to establish peace.”

  • Background: Erdogan’s comments came after the Moscow talks between the two nations’ defense ministers and intelligence chiefs. “Following this meeting… we will bring our foreign ministers together. And after that, as leaders, we will come together,” Erdogan said on Thursday.
  • Why it matters: The meeting would mark a dramatic shift in Turkey’s decade-long stance on Syria, where Ankara was the prime supporter of political and armed factions fighting to topple Assad. The Turkish military maintains a presence across the Syrian border and within northern Syria, where it backs Syrian opposition forces. Erdogan has also pledged to launch yet another incursion into northern Syria, aiming at creating a 30-km (20-mile) deep “safe zone” that would be emptied of Kurdish fighters.

Iran shuts down French cultural center over Charlie Hebdo’s Khamenei cartoons

Iran announced on Thursday it had ended the activities of a Tehran-based French research institute, in reaction to cartoons mocking Ayatollah Ali Khamenei and fellow Shia Muslim clerics published by French satirical magazine Charlie Hebdo this week.

  • Background: Iran summoned the French ambassador to Tehran on Wednesday to protest cartoons published by satirical magazine Charlie Hebdo. More than 30 cartoons poking fun at Iran’s supreme leader were published by the magazine on Wednesday, in a show of support for the Iranian people who have been protesting the Islamic Republic’s government and its policies.
  • Why it matters: French-Iranian relations have deteriorated significantly since protests broke out in Iran late last year. Paris has publicly supported the protests and spoken out against Iran’s response to them. French Foreign Minister Catherine Colonna criticized Iran’s freedom of press and judicial independence on Thursday, saying “press freedom exists, contrary to what is going on in Iran and… it is exercised under the supervision of a judge in an independent judiciary – and there too it’s something that Iran knows little of.”

The prized legacy of iconic Egyptian singer Umm Kulthum re-emerged this year when Rolling Stone magazine featured her in its “200 Greatest Singers of All Time.”

Ranking 61st, Umm Kulthum was the only Arab artist to make it to the list, with the magazine saying that she “has no real equivalent among singers in the West.”

Born in a small village northeast of the Egyptian capital Cairo, Umm Kulthum rose to unmatched fame as she came to represent “the soul of the pan-Arab world,” the music magazine said.

“Her potent contralto, which could blur gender in its lower register, conveyed breathtaking emotional range in complex songs that, across theme and wildly-ornamented variations, could easily last an hour, as she worked crowds like a fiery preacher,” it wrote.

Nicknamed “the lady of Arab singing,” her music featured both classical Arabic poetry as well as colloquial songs still adored by younger generations. Her most famous pieces include “Inta Uumri” (you are my life), “Alf Leila Weileila” (a thousand and one nights), “Amal Hayati” (hope of my life) and “Daret al-Ayyam” (the days have come around). Some of her songs have been remixed to modern beats that have made their way to Middle Eastern nightclubs.

The singer remains an unmatched voice across the Arab World and her music can still be heard in many traditional coffee shops in Old Cairo’s neighborhoods and other parts of the Arab world.

Umm Kulthum’s death in 1975 brought millions of mourners to the streets of Cairo.

By Nadeen Ebrahim

Women athletes aim their air rifles while competing in a local shooting championship in Yemen's Houthi rebel-held capital Sanaa on January 3.



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